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Reduced motor corte...
Reduced motor cortex GABABR function following chronic alcohol exposure
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- Peng, Shi-Yu (author)
- Shanghai Jiao Tong Univ, Peoples R China
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- Shi, Zhe (author)
- Hunan Univ Chinese Med, Peoples R China
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- Zhou, Dong-Sheng (author)
- Ningbo Kangning Hosp, Peoples R China
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- Wang, Xin-Yue (author)
- Shanghai Jiao Tong Univ, Peoples R China
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- Li, Xing-Xing (author)
- Ningbo Kangning Hosp, Peoples R China
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- Liu, Xiao-Li (author)
- Ningbo Kangning Hosp, Peoples R China
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- Wang, Wei-Di (author)
- Shanghai Jiao Tong Univ, Peoples R China
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- Lin, Guan-Ning (author)
- Shanghai Jiao Tong Univ, Peoples R China; Shanghai Jiao Tong Univ, Peoples R China
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- Pan, Bing-Xing (author)
- Nanchang Univ, Peoples R China
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- Voon, Valerie (author)
- Univ Cambridge, England
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- Grace, Anthony A. (author)
- Univ Pittsburgh, PA USA
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- Heilig, Markus, 1959- (author)
- Linköpings universitet,Medicinska fakulteten,Centrum för social och affektiv neurovetenskap,Region Östergötland, Psykiatriska kliniken i Linköping
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- Wong, Ma-Li (author)
- SUNY Upstate Med Univ, NY 13210 USA
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- Yuan, Ti-Fei (author)
- Shanghai Jiao Tong Univ, Peoples R China; Nantong Univ, Peoples R China; TianQiao & Chrissy Chen Inst Translat Res, Peoples R China; Univ Hong Kong, Peoples R China
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(creator_code:org_t)
- 2021-01-11
- 2021
- English.
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In: Molecular Psychiatry. - : SPRINGERNATURE. - 1359-4184 .- 1476-5578. ; 26:2, s. 383-395
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The GABA(B) receptor (GABA(B)R) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABA(B)R dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from mice chronically exposed to alcohol revealed a reduction in GABA(B)R-mediated currents, as well as a decrease of GABA(B1/2)R and G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) activities in the motor cortex. Moreover, our data indicated that these alterations could be attributed to dephosphorylation at the site of serine 783 (ser-783) in GABA(B2) subunit, which regulates the surface expression of GABA(B)R. Furthermore, a human study using paired-pulse-transcranial magnetic stimulation (TMS) analysis further demonstrated a reduced cortical inhibition mediated by GABA(B)R in patients with AUD. Our findings provide the first evidence that chronic alcohol exposure is associated with significantly impaired cortical GABA(B)R function. The ability to promote GABA(B)R signaling may account for the therapeutic efficacy of baclofen in AUD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Peng, Shi-Yu
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Shi, Zhe
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Zhou, Dong-Sheng
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Wang, Xin-Yue
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Li, Xing-Xing
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Liu, Xiao-Li
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Wang, Wei-Di
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Lin, Guan-Ning
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Pan, Bing-Xing
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Voon, Valerie
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Grace, Anthony A ...
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Heilig, Markus, ...
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Wong, Ma-Li
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Yuan, Ti-Fei
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Molecular Psychi ...
- By the university
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Linköping University