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Reduced motor corte...
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Peng, Shi-YuShanghai Jiao Tong Univ, Peoples R China
(författare)
Reduced motor cortex GABABR function following chronic alcohol exposure
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-01-11
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SPRINGERNATURE,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-203503
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-203503URI
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https://doi.org/10.1038/s41380-020-01009-6DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|NSFC [81822017, 81901349, 31771215]; Science and Technology Commission of Shanghai Municipality [18QA1403700, 18JC1420304, 18140901700]; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20181715]; Hundred-talent Fund from Shanghai Municipal Commission of Health [2018BR21]; Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University [ZH2018ZDA30, ZH2018QNA39]; innovative research team of high-level local universities in Shanghai; Medical Research Council [MR/P008747/1]; MRC [MR/P008747/1] Funding Source: UKRI
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The GABA(B) receptor (GABA(B)R) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study aimed to investigate cortical GABA(B)R dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from mice chronically exposed to alcohol revealed a reduction in GABA(B)R-mediated currents, as well as a decrease of GABA(B1/2)R and G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) activities in the motor cortex. Moreover, our data indicated that these alterations could be attributed to dephosphorylation at the site of serine 783 (ser-783) in GABA(B2) subunit, which regulates the surface expression of GABA(B)R. Furthermore, a human study using paired-pulse-transcranial magnetic stimulation (TMS) analysis further demonstrated a reduced cortical inhibition mediated by GABA(B)R in patients with AUD. Our findings provide the first evidence that chronic alcohol exposure is associated with significantly impaired cortical GABA(B)R function. The ability to promote GABA(B)R signaling may account for the therapeutic efficacy of baclofen in AUD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Shi, ZheHunan Univ Chinese Med, Peoples R China
(författare)
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Zhou, Dong-ShengNingbo Kangning Hosp, Peoples R China
(författare)
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Wang, Xin-YueShanghai Jiao Tong Univ, Peoples R China
(författare)
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Li, Xing-XingNingbo Kangning Hosp, Peoples R China
(författare)
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Liu, Xiao-LiNingbo Kangning Hosp, Peoples R China
(författare)
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Wang, Wei-DiShanghai Jiao Tong Univ, Peoples R China
(författare)
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Lin, Guan-NingShanghai Jiao Tong Univ, Peoples R China; Shanghai Jiao Tong Univ, Peoples R China
(författare)
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Pan, Bing-XingNanchang Univ, Peoples R China
(författare)
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Voon, ValerieUniv Cambridge, England
(författare)
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Grace, Anthony A.Univ Pittsburgh, PA USA
(författare)
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Heilig, Markus,1959-Linköpings universitet,Medicinska fakulteten,Centrum för social och affektiv neurovetenskap,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)marhe41
(författare)
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Wong, Ma-LiSUNY Upstate Med Univ, NY 13210 USA
(författare)
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Yuan, Ti-FeiShanghai Jiao Tong Univ, Peoples R China; Nantong Univ, Peoples R China; TianQiao & Chrissy Chen Inst Translat Res, Peoples R China; Univ Hong Kong, Peoples R China
(författare)
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Shanghai Jiao Tong Univ, Peoples R ChinaHunan Univ Chinese Med, Peoples R China
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Psychiatry: SPRINGERNATURE26:2, s. 383-3951359-41841476-5578
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Till lärosätets databas
- Av författaren/redakt...
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Peng, Shi-Yu
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Shi, Zhe
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Zhou, Dong-Sheng
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Wang, Xin-Yue
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Li, Xing-Xing
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Liu, Xiao-Li
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visa fler...
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Wang, Wei-Di
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Lin, Guan-Ning
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Pan, Bing-Xing
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Voon, Valerie
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Grace, Anthony A ...
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Heilig, Markus, ...
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Wong, Ma-Li
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Yuan, Ti-Fei
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Molecular Psychi ...
- Av lärosätet
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Linköpings universitet