Search: WFRF:(Karlsson Johan 1972) >
Liver fibrosis is a...
Liver fibrosis is associated with left ventricular remodeling : insight into the liver-heart axis
-
- Edin, Carl (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US
-
- Ekstedt, Mattias, 1976- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
-
- Karlsson, Markus, 1990- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Region Östergötland, Medicinsk strålningsfysik
-
show more...
-
- Wegmann, Bertil, 1978- (author)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Statistik och maskininlärning,Filosofiska fakulteten
-
- Warntjes, Marcel, 1973- (author)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten
-
- Swahn, Eva, 1949- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
-
- Östgren, Carl Johan, 1963- (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Region Östergötland, Vårdcentralen Ekholmen
-
- Ebbers, Tino, 1972- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten
-
- Lundberg, Peter, 1958- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Region Östergötland, Medicinsk strålningsfysik
-
- Carlhäll, Carl-Johan, 1973- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084.
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Objective: In non-alcoholic fatty liver disease (NAFLD), liver fibrosis is the strongest predictor of adverse outcomes. We sought to investigate the relationship between liver fibrosis and cardiac remodeling in participants from the general population using magnetic resonance imaging (MRI), as well as explore potential mechanistic pathways by analyzing circulating cardiovascular biomarkers.Methods: In this cross-sectional study, we prospectively included participants with type 2 diabetes and individually matched controls from the SCAPIS (Swedish CArdioPulmonary bioImage Study) cohort in Linköping, Sweden. Between November 2017 and July 2018, participants underwent MRI at 1.5 Tesla for quantification of liver proton density fat fraction (spectroscopy), liver fibrosis (stiffness from elastography), left ventricular (LV) structure and function, as well as myocardial native T1 mapping. We analyzed 278 circulating cardiovascular biomarkers using a Bayesian statistica lapproach.Results: In total, 92 participants were enrolled (mean age 59.5 ± 4.6 years, 32 women). The mean liver stiffness was 2.1 ± 0.4 kPa. 53 participants displayed hepatic steatosis. LV concentricity increased across quartiles of liver stiffness. Neither liver fat nor liver stiffness displayed any relationships to myocardial tissue characteristics (native T1). In a regression analysis, liver stiffness was related to increased LV concentricity. This association was independent of diabetes and liver fat (Beta = 0.26, p = 0.0053), but was attenuated (Beta = 0.17, p = 0.077) when also adjusting for circulating levels of interleukin-1 receptor type 2.Conclusion: MRI reveals that liver fibrosis is associated to structural LV remodeling, in terms of increased concentricity, in participants from the general population. This relationship could involve the interleukin-1 signaling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Interleukin-1
- Non-alcoholic fatty liver disease
- Type 2 diabetes
- Elastography
- Magnetic Resonance
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Edin, Carl
-
Ekstedt, Mattias ...
-
Karlsson, Markus ...
-
Wegmann, Bertil, ...
-
Warntjes, Marcel ...
-
Swahn, Eva, 1949 ...
-
show more...
-
Östgren, Carl Jo ...
-
Ebbers, Tino, 19 ...
-
Lundberg, Peter, ...
-
Carlhäll, Carl-J ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Radiology Nuclea ...
- Articles in the publication
-
European Radiolo ...
- By the university
-
Linköping University