Model-based quantitative laser Doppler flowmetry in skin

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Fredriksson, Ingemar,1980-Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan (författare)

Model-based quantitative laser Doppler flowmetry in skin

Artikel/kapitelEngelska2010

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Society of Photo-optical Instrumentation Engineers,2010
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-20445
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20445URI
https://doi.org/10.1117/1.3484746DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Laser Doppler Flowmetry (LDF) can be used for assessing the microcirculatory perfusion. However, conventional LDF (cLDF) gives only a relative perfusion estimate in an unknown measurement volume. To overcome these limitations a model-based analysis method for quantitative LDF (qLDF) is proposed. The method uses an inverse Monte Carlo technique with an adaptive three layer skin model. By analyzing the optimal model where measured and simulated LDF spectra using two different source-detector separations match, the absolute microcirculatory perfusion for a specified velocity region in a predefined volume is determined. The robustness of the qLDF method and how much it is affected by physiologically relevant variations in optical properties were evaluated using additional Monte Carlo simulations. When comparing qLDF to cLDF, a much smaller deviation from the true perfusion was attained. For physiologically relevant variations in the optical properties of static tissue and blood absorption, qLDF displayed errors <12%. Variations in the scattering properties of blood displayed larger errors (<58%). Evaluations on inhomogeneous models containing small blood vessels, hair and sweat glands displayed errors <5%. For extremely inhomogeneous models containing larger blood vessels, the error increased substantially, but this was detected by analyzing the qLDF model residual. The qLDF algorithm was applied to an in vivo local heat provocation. The perfusion increase was higher with qLDF than cLDF, due to non-linear effects in the latter. The qLDF showed that the perfusion increase was due to an increased amount of blood cells with a velocity > 1 mm/s.

Ämnesord och genrebeteckningar

TEKNIK OCH TEKNOLOGIER Medicinteknik Medicinsk laboratorie- och mätteknik hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering Medical Laboratory and Measurements Technologies hsv//eng
laser Doppler flowmetry
microcirculation
tissue modeling
inverse Monte Carlo
quantitative measures
flow speed differentiation
Medical engineering
Medicinsk teknik

Biuppslag (personer, institutioner, konferenser, titlar ...)

Larsson, MarcusLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan(Swepub:liu)marla29 (författare)
Strömberg, TomasLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan(Swepub:liu)tomst50 (författare)
Linköpings universitetBiomedicinsk instrumentteknik (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Biomedical Optics: Society of Photo-optical Instrumentation Engineers15:51083-36681560-2281

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Av författaren/redakt...: Fredriksson, Ing ...; Larsson, Marcus; Strömberg, Tomas

Om ämnet

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik; och Medicinsk labora ...

Artiklar i publikationen: Journal of Biome ...

Av lärosätet: Linköpings universitet

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