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Acromegaly manageme...
Acromegaly management in the Nordic countries: A Delphi consensus survey
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- Arlien-Soborg, Mai C. (author)
- Aarhus Univ Hosp, Denmark
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- Dal, Jakob (author)
- Aalborg Univ Hosp, Denmark; Steno Diabet Ctr North Jutland, Denmark
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- Heck, Ansgar (author)
- Oslo Univ Hosp, Norway
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- Stochholm, Kirstine (author)
- Aarhus Univ Hosp, Denmark
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- Husted, Eigil (author)
- Aalborg Univ Hosp, Denmark
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- Feltoft, Claus Larsen (author)
- Copenhagen Univ Hosp Herlev & Gentofte, Denmark
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- Rasmussen, ase Krogh (author)
- Copenhagen Univ Hosp, Denmark
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- Feldt-Rasmussen, Ulla (author)
- Copenhagen Univ Hosp, Denmark
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- Andreassen, Mikkel (author)
- Copenhagen Univ Hosp, Denmark
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- Klose, Marianne Christina (author)
- Copenhagen Univ Hosp, Denmark
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- Nielsen, Torben Leo (author)
- Odense Univ Hosp, Denmark
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- Andersen, Marianne Skovsager (author)
- Odense Univ Hosp, Denmark
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- Christensen, Louise Lehmann (author)
- Odense Univ Hosp, Denmark
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- Krogh, Jesper (author)
- Copenhagen Univ Hosp, Denmark
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- Jarlov, Anne (author)
- Copenhagen Univ Hosp, Denmark
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- Bollerslev, Jens (author)
- Oslo Univ Hosp, Norway
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- Nermoen, Ingrid (author)
- Akershus Univ Hosp, Norway
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- Oksnes, Marianne (author)
- Haukeland Hosp, Norway
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- Dahlqvist, Per (author)
- Umea Univ, Sweden; Norrlands Univ Hosp, Sweden
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- Olsson, Tommy (author)
- Umea Univ, Sweden; Norrlands Univ Hosp, Sweden
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- Berinder, Katarina (author)
- Karolinska Univ Hosp, Sweden
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- Hoybye, Charlotte (author)
- Karolinska Univ Hosp, Sweden
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- Petersson, Maria (author)
- Karolinska Univ Hosp, Sweden
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- Akerman, Anna-karin (author)
- Orebro Univ, Sweden
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- Wahlberg, Jeanette (author)
- Orebro Univ Hosp, Sweden
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- Ekman, Bertil (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN,Region Östergötland, Endokrinmedicinska kliniken
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- Engstrom, Britt Eden (author)
- Uppsala Univ Hosp, Sweden
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- Johannsson, Gudmundur (author)
- Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Ragnarsson, Oskar (author)
- Sahlgrens Univ Hosp, Sweden
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- Olsson, Daniel (author)
- Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; AstraZeneca, Sweden
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- Sigurjonsdottir, Helga agusta (author)
- Natl Univ Hosp Iceland, Iceland; Univ Iceland, Iceland
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- Fougner, Stine Lyngvi (author)
- Trondheim Reg & Univ Hosp, Norway; Norwegian Univ Sci & Technol NTNU, Norway
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- Matikainen, Niina (author)
- Helsinki Univ Hosp, Finland
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- Vehkavaara, Satu (author)
- Helsinki Univ Hosp, Finland
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- Metso, Saara (author)
- Tampere Univ Hosp, Finland
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- Jaatinen, Pia (author)
- Tampere Univ Hosp, Finland
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- Haemalainen, Paeivi (author)
- Tampere Univ Hosp, Finland
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- Rintamaki, Reeta (author)
- Kuopio Univ Hosp, Finland
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- Yliaska, Iina (author)
- Oulu Univ Hosp, Finland
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- Immonen, Heidi (author)
- Turku Univ Hosp, Finland
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- Makimattila, Sari (author)
- Helsinki Univ Hosp, Finland
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- Cederberg-Tamminen, Henna (author)
- Helsinki Univ Hosp, Finland
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- Viukari, Marianna (author)
- Helsinki Univ Hosp, Finland
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- Nevalainen, Pasi (author)
- Tampere Univ Hosp, Finland
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- Nuutila, Pirjo (author)
- Turku Univ Hosp, Finland
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- Schalin-Jantti, Camilla (author)
- Helsinki Univ Hosp, Finland
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- Burman, Pia (author)
- Lund Univ, Sweden
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- Jorgensen, Jens Otto Lunde (author)
- Aarhus Univ Hosp, Denmark
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Clinical Endocrinology. - : WILEY. - 0300-0664 .- 1365-2265.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- ObjectiveAcromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.MethodsA Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1-7). Consensus was defined as >= 80% of panelists rating their agreement as >= 5 or <= 3 on the Likert-type scale.ResultsConsensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.ConclusionThis consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- acromegaly; Delphi; dopamine agonist; growth hormone; growth hormone receptor antagonist; insulin-like growth factor i; somatostatin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Arlien-Soborg, M ...
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Dal, Jakob
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Heck, Ansgar
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Stochholm, Kirst ...
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Husted, Eigil
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Feltoft, Claus L ...
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Rasmussen, ase K ...
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Feldt-Rasmussen, ...
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Andreassen, Mikk ...
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Klose, Marianne ...
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Nielsen, Torben ...
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Andersen, Marian ...
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Christensen, Lou ...
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Krogh, Jesper
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Jarlov, Anne
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Bollerslev, Jens
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Nermoen, Ingrid
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Oksnes, Marianne
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Dahlqvist, Per
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Olsson, Tommy
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Berinder, Katari ...
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Hoybye, Charlott ...
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Petersson, Maria
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Akerman, Anna-ka ...
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Wahlberg, Jeanet ...
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Ekman, Bertil
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Engstrom, Britt ...
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Johannsson, Gudm ...
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Ragnarsson, Oska ...
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Olsson, Daniel
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Sigurjonsdottir, ...
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Fougner, Stine L ...
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Matikainen, Niin ...
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Vehkavaara, Satu
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Metso, Saara
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Jaatinen, Pia
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Haemalainen, Pae ...
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Rintamaki, Reeta
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Yliaska, Iina
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Immonen, Heidi
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Makimattila, Sar ...
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Cederberg-Tammin ...
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Viukari, Mariann ...
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Nevalainen, Pasi
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Nuutila, Pirjo
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Schalin-Jantti, ...
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Burman, Pia
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Jorgensen, Jens ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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Clinical Endocri ...
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Linköping University