SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Burisch Johan)
 

Sökning: WFRF:(Burisch Johan) > Identification and ...

Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Salihovic, Samira, Associate Senior Lecturer, 1985- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
Nystrom, Niklas (författare)
Uppsala Univ, Sweden,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
Mathisen, Charlotte Bache-Wiig (författare)
Oslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
visa fler...
Kruse, Robert, 1972- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
Olbjorn, Christine (författare)
Akershus Univ Hosp, Norway,Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway
Andersen, Svend (författare)
Vestfold Hosp Trust, Norway,Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway
Noble, Alexandra J. (författare)
Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
Dorn-Rasmussen, Maria (författare)
Copenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Bazov, Igor, 1973- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
Perminow, Gori (författare)
Oslo Univ Hosp, Norway,Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway
Opheim, Randi (författare)
Oslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
Detlie, Trond Espen (författare)
Akershus Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
Huppertz-Hauss, Gert (författare)
Telemark Hosp Trust, Norway,Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway
Hedin, Charlotte R. H. (författare)
Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden,Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden; Karolinska University Hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden
Carlson, Marie (författare)
Uppsala Univ, Sweden,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Ohman, Lena (författare)
Univ Gothenburg, Sweden,Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Magnusson, Maria K. (författare)
Univ Gothenburg, Sweden,Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Keita, Åsa (författare)
Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
Söderholm, Johan D (författare)
Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
D'Amato, Mauro (författare)
Basque Fdn Sci, Spain; CIC bioGUNE BRTA, Spain; LUM Univ, Italy,IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland,Orebro Univ, Sweden; Univ Turku, Finland; Abo Akad Univ, Finland
Wewer, Vibeke (författare)
Copenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Satsangi, Jack (författare)
Univ Oxford, England; Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
Lindqvist, Carl Mårten, 1979- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
Burisch, Johan (författare)
Copenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Uhlig, Holm H. (författare)
Univ Oxford, England; Univ Oxford, England; Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK
Repsilber, Dirk, 1971- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,Orebro Univ, Sweden
Hoivik, Marte Lie (författare)
Oslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
Halfvarson, Jonas, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
visa färre...
 (creator_code:org_t)
NATURE PORTFOLIO, 2024
2024
Engelska.
Ingår i: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 15:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-na & iuml;ve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making. Diagnostic blood-based biomarkers of pediatric IBD are limited. Here, the authors demonstrate a diagnostic lipidomic signature, comprising only of two molecular lipids. Translation of this signature into a scalable test has the potential to support clinical decision making.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy