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Chronic Viral Infec...
Chronic Viral Infection Compromises the Quality of Circulating Mucosal-Associated Invariant T Cells and Follicular T Helper Cells via Expression of Inhibitory Receptors
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- Vimali, Jaisheela (författare)
- Cent Univ Tamil Nadu, India
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- Yong, Yean K. (författare)
- Xiamen Univ Malaysia, Malaysia; Xiamen Univ Malaysia, Malaysia
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- Murugesan, Amudhan (författare)
- Govt Theni Med Coll & Hosp, India
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- Tan, Hong Y. (författare)
- Xiamen Univ Malaysia, Malaysia
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- Zhang, Ying (författare)
- Xiamen Univ Malaysia, Malaysia
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- Ashwin, Rajeev (författare)
- Cent Univ Tamil Nadu, India
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- Raju, Sivadoss (författare)
- State Publ Hlth Lab, India
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- Balakrishnan, Pachamuthu (författare)
- Saveetha Univ, India
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- Larsson, Marie (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Velu, Vijayakumar (författare)
- Emory Univ, GA 30322 USA
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- Shankar, Esaki M. (författare)
- Cent Univ Tamil Nadu, India
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(creator_code:org_t)
- IMR PRESS, 2024
- 2024
- Engelska.
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Ingår i: FRONTIERS IN BIOSCIENCE-LANDMARK. - : IMR PRESS. - 2768-6701. ; 29:3
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- Background: Chronic viral infection results in impaired immune responses rendering viral persistence. Here, we compared the quality of T-cell responses among chronic hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV)-infected individuals by examining the levels of expression of selected immune activation and exhaustion molecules on circulating MAIT cells and Tfh cells. Methods: Cytokines were measured using a commercial Bio-plex Pro Human Cytokine Grp I Panel 17-plex kit (BioRad, Hercules, CA, USA). Inflammation was assessed by measuring an array of plasma cytokines, and phenotypic alterations in CD4(+) T cells including circulating Tfh cells, CD8(+) T cells, and TCR iV alpha 7.2(+) MAIT cells in chronic HBV, HCV, and HIV-infected patients and healthy controls. The cells were characterized based on markers pertaining to immune activation (CD69, ICOS, and CD27) proliferation (Ki67), cytokine production (TNF-alpha, IFN-gamma) and exhaustion (PD-1). The cytokine levels and T cell phenotypes together with cell markers were correlated with surrogate markers of disease progression. Results: The activation marker CD69 was significantly increased in CD4(+hi) T cells, while CD8(+) MAIT cells producing IFN-gamma were significantly increased in chronic HBV, HCV and HIV infections. Six cell phenotypes, viz., TNF-alpha(+)CD4(+lo) T cells, CD69(+)CD8(+) T cells, CD69(+)CD4(+) MAIT cells, PD-1(+)CD4(+hi) T cells, PD-1(+)CD8(+) T cells, and Ki67(+)CD4(+) MAIT cells, were independently associated with decelerating the plasma viral load (PVL). TNF-alpha levels showed a positive correlation with increase in cytokine levels and decrease in PVL. Conclusion: Chronic viral infection negatively impacts the quality of peripheral MAIT cells and Tfh cells via differential expression of both activating and inhibitory receptors.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- HBV; HIV; MAIT cells; PD-1; T cell exhaustion
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Vimali, Jaisheel ...
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Yong, Yean K.
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Murugesan, Amudh ...
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Tan, Hong Y.
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Zhang, Ying
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Ashwin, Rajeev
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Raju, Sivadoss
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Balakrishnan, Pa ...
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Larsson, Marie
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Velu, Vijayakuma ...
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Shankar, Esaki M ...
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