SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:liu-205423"
 

Sökning: id:"swepub:oai:DiVA.org:liu-205423" > Global and regional...

  • Lee, SoojiKyung Hee Univ, South Korea (författare)

Global and regional burden of vaccine-induced thrombotic thrombocytopenia, 1969-2023: Comprehensive findings with critical analysis of the international pharmacovigilance database

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024
  • WILEY,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-205423
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-205423URI
  • https://doi.org/10.1111/ejh.14250DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|National Research Foundation of Korea (NRF)
  • Objective: The scarcity of studies on vaccine-induced thrombosis and thrombocytopenia syndrome (TTS) limits the comprehensive understanding of vaccine safety on a global scale. Therefore, the objective of this study is to assess the global burden of vaccine-induced TTS, identify the vaccines most associated with it, and suggest clinical implications regarding vaccination. Methods: This study employed the World Health Organization international pharmacovigilance database, extracting records of vaccine-induced immune thrombotic thrombocytopenia from 1969 to 2023 (total reports, n > 130 million). Global reporting counts, reported odds ratios (ROR), and information components (IC) were calculated to identify the association between 19 vaccines and the occurrence of vaccine-induced TTS across 156 countries. Results: We identified 24 233 cases (male, n = 11 559 [47.7%]) of vaccine-induced TTS among 404 388 reports of all-cause TTS. There has been a significant increase in reports of vaccine-induced TTS events over time, with a noteworthy surge observed after 2020, attributed to cases of TTS associated with COVID-19 vaccines. Measles, mumps, and rubella (MMR) vaccines were associated with most TTS reports (ROR [95% confidence interval], 2.87 [2.75-3.00]; IC [IC0.25], 1.51 [1.43]), followed by hepatitis B (HBV, 2.23 [2.07-2.39]; 1.15 [1.03]), rotavirus diarrhea (1.95 [1.78-2.13]; 0.81 [0.53]), encephalitis (1.80 [1.50-2.16]; 0.84 [0.53]), hepatitis A (1.67 [1.50-1.86]; 0.73 [0.55]), adenovirus Type 5 vector-based (Ad5-vectored) COVID-19 (1.64 [1.59-1.68]; 0.69 [0.64]), pneumococcal (1.57 [1.49-1.66]; 0.65 [0.56]), and typhoid vaccines (1.41 [1.12-1.78]; 0.49 [0.11]). Concerning age and sex-specific risks, reports of vaccine-induced TTS were more associated with females and younger age groups. The age group between 12 and 17 years exhibited significant sex disproportion. Most of these adverse events had a short time to onset (days; mean [SD], 4.99 [40.30]) and the fatality rate was 2.20%, the highest rate observed in the age group over 65 years (3.79%) and lowest in the age group between 0 and 11 years (0.31%). Conclusion: A rise in vaccine-induced TTS reports, notably MMR, HBV, and rotavirus diarrhea vaccines, was particularly related to young females. Ad5-vectored COVID-19 vaccines showed comparable or lower association with TTS compared to other vaccines. Despite the rarity of these adverse events, vigilance is essential as rare complications can be fatal, especially in older groups. Further studies with validated reporting are imperative to improve the accuracy of assessing the vaccine-induced TTS for preventive interventions and early diagnosis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jo, HyesuKyung Hee Univ, South Korea (författare)
  • Woo, SelinKyung Hee Univ, South Korea (författare)
  • Jeong, Yi DeunKyung Hee Univ, South Korea (författare)
  • Lee, HayeonKyung Hee Univ, South Korea (författare)
  • Lee, KyeongminKyung Hee Univ, South Korea (författare)
  • Lee, JinseokKyung Hee Univ, South Korea (författare)
  • Kim, Hyeon JinKyung Hee Univ, South Korea (författare)
  • Kang, JiseungHarvard Med Sch, MA USA; Massachusetts Gen Hosp, MA USA (författare)
  • Jacob, LouisISCIII, Spain; Univ Paris Cite, France (författare)
  • Smith, LeeAnglia Ruskin Univ, England (författare)
  • Rahmati, MasoudAix Marseille Univ, France; Lorestan Univ, Iran; Vali E Asr Univ Rafsanjan, Iran (författare)
  • Sanchez, Guillermo F. LopezUniv Murcia, Spain (författare)
  • Dragioti, ElenaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Univ Ioannina, Greece(Swepub:liu)eledr71 (författare)
  • Son, YejunKyung Hee Univ, South Korea (författare)
  • Kim, SoeunKyung Hee Univ, South Korea (författare)
  • Yeo, Seung GeunKyung Hee Univ, South Korea (författare)
  • Park, JaeyuKyung Hee Univ, South Korea (författare)
  • Yon, Dong KeonKyung Hee Univ, South Korea (författare)
  • Kyung Hee Univ, South KoreaHarvard Med Sch, MA USA; Massachusetts Gen Hosp, MA USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Haematology: WILEY0902-44411600-0609

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy