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EXPRESSION OF FXYD-...
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Loftas, PerÖstergötlands Läns Landsting,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala,Landstinget i Östergötland
(author)
EXPRESSION OF FXYD-3 IS AN INDEPENDENT PROGNOSTIC FACTOR IN RECTAL CANCER PATIENTS WITH PREOPERATIVE RADIOTHERAPY
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Elsevier BV,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-20598
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20598URI
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https://doi.org/10.1016/j.ijrobp.2008.10.076DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Purpose: FXYD-3 (MAT-8) is overexpressed in several types of cancers; however, its clinical relevance in rectal cancers has not been studied. Therefore, we examined FXYD-3 expression in rectal cancers from the patients who participated in a Swedish clinical trial of preoperative radiotherapy (RT) to determine whether FXYD-3 was overexpressed in rectal cancers and correlated with RT, survival, and other clinicopathologic variables. Methods and Materials: The study included 140 rectal cancer patients who participated in a clinical trial of preoperative RT, 65 with and 75 without RT before surgery. FXYD-3 expression was immumohistochemically examined in distant (n = 70) and adjacent (n = 101) normal mucosa, primary tumors (n = 140), and lymph node metastasis (n = 36). Results: In the whole cohort, strong FXYD-3 expression was correlated with infiltrative tumor growth (p = 0.02). In the RT group, strong FXYD-3 expression alone (p = 0.02) or combined with phosphatase of regenerating liver was associated with an unfavorable prognosis (p = 0.02), independent of both TNM stage and tumor differentiation. In tumors with strong FXYD-3 expression, there was less tumor necrosis (p = 0.02) and a trend toward increased incidence of distant metastasis (p = 0.08) after RT. None of these effects was seen in the non-RT group. FXYD-3 expression in the primary tumors tended to he increased compared with normal mucosa regardless of RT. Conclusion: FXYD-3 expression was a prognostic factor independent of tumor stage and differentiation in patients receiving preoperative RT for rectal cancer.
Subject headings and genre
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FXYD-3
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Rectal cancer
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Radiotherapy
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Prognosis
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Immunohistochemistry
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Önnesjö, SofiaLinköpings universitet,Hälsouniversitetet,Onkologi(Swepub:liu)sofon33
(author)
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Widegren, EmmaLinköpings universitet,Hälsouniversitetet,Onkologi(Swepub:liu)emmwi09
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Adell, GunnarKarolinska University Hospital
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Kayed, HanyUniversity of Heidelberg
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Kleeff, JoergTech University of Munich
(author)
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Zentgraf, HanswalterUniversity of Heidelberg
(author)
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Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45
(author)
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Östergötlands Läns LandstingKirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala
(creator_code:org_t)
Related titles
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In:INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS: Elsevier BV75:1, s. 137-1420360-3016
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