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Search: id:"swepub:oai:DiVA.org:liu-20598" > EXPRESSION OF FXYD-...

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  • Loftas, PerÖstergötlands Läns Landsting,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala,Landstinget i Östergötland (author)

EXPRESSION OF FXYD-3 IS AN INDEPENDENT PROGNOSTIC FACTOR IN RECTAL CANCER PATIENTS WITH PREOPERATIVE RADIOTHERAPY

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Elsevier BV,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-20598
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20598URI
  • https://doi.org/10.1016/j.ijrobp.2008.10.076DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose: FXYD-3 (MAT-8) is overexpressed in several types of cancers; however, its clinical relevance in rectal cancers has not been studied. Therefore, we examined FXYD-3 expression in rectal cancers from the patients who participated in a Swedish clinical trial of preoperative radiotherapy (RT) to determine whether FXYD-3 was overexpressed in rectal cancers and correlated with RT, survival, and other clinicopathologic variables. Methods and Materials: The study included 140 rectal cancer patients who participated in a clinical trial of preoperative RT, 65 with and 75 without RT before surgery. FXYD-3 expression was immumohistochemically examined in distant (n = 70) and adjacent (n = 101) normal mucosa, primary tumors (n = 140), and lymph node metastasis (n = 36). Results: In the whole cohort, strong FXYD-3 expression was correlated with infiltrative tumor growth (p = 0.02). In the RT group, strong FXYD-3 expression alone (p = 0.02) or combined with phosphatase of regenerating liver was associated with an unfavorable prognosis (p = 0.02), independent of both TNM stage and tumor differentiation. In tumors with strong FXYD-3 expression, there was less tumor necrosis (p = 0.02) and a trend toward increased incidence of distant metastasis (p = 0.08) after RT. None of these effects was seen in the non-RT group. FXYD-3 expression in the primary tumors tended to he increased compared with normal mucosa regardless of RT. Conclusion: FXYD-3 expression was a prognostic factor independent of tumor stage and differentiation in patients receiving preoperative RT for rectal cancer.

Subject headings and genre

  • FXYD-3
  • Rectal cancer
  • Radiotherapy
  • Prognosis
  • Immunohistochemistry
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Önnesjö, SofiaLinköpings universitet,Hälsouniversitetet,Onkologi(Swepub:liu)sofon33 (author)
  • Widegren, EmmaLinköpings universitet,Hälsouniversitetet,Onkologi(Swepub:liu)emmwi09 (author)
  • Adell, GunnarKarolinska University Hospital (author)
  • Kayed, HanyUniversity of Heidelberg (author)
  • Kleeff, JoergTech University of Munich (author)
  • Zentgraf, HanswalterUniversity of Heidelberg (author)
  • Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
  • Östergötlands Läns LandstingKirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala (creator_code:org_t)

Related titles

  • In:INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS: Elsevier BV75:1, s. 137-1420360-3016

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