Comment on "The Dynamic Control of Kiss-and-Run and Vesicular Reuse Probed with Single Nanoparticles" : in Science(ISSN 0036-8075) vol 325, issue 5947, pp 1499

• Zhang et al. (Research Articles, 13 March 2009, p. 1448) reported that synaptic vesicles usually release neurotransmitter through a kiss-and-run mechanism occurring within 1 second but that full collapse of the vesicles becomes more prevalent with repeated stimuli. We report that the kinetics of vesicle retrieval do not change during a stimulus train, with endocytosis occurring in 10 to 15 seconds.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Keyword

synapse

endocytosis

exocytosis

synaptic vesicle

GFP

kinetic modeling

Neurobiology

Neurobiologi

Neurophysiology

Neurofysiologi

Molecular neurobiology

Molekylär neurobiologi

Publication and Content Type

vet (subject category)

art (subject category)