Short- and long-term effects of T-cell modulating agents in experimental autoimmunity

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Mellergård, Johan (författare)

Short- and long-term effects of T-cell modulating agents in experimental autoimmunity

Artikel/kapitelEngelska2004

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Elsevier BV,2004
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LIBRIS-ID:oai:DiVA.org:liu-22760
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-22760URI
https://doi.org/10.1016/j.tox.2003.10.004DOI

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Språk:engelska
Sammanfattning på:engelska

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Due to the easy and reliable induction of a disease condition with many of the features present in human autoimmunity, mercury-induced autoimmunity (mHgAI) in rodents is a favourable autoimmune model. Genetically susceptible (H-2 s) mice develop in response to mercury (Hg) a systemic autoimmune condition with antinucleolar antibodies (ANoA) targeting the protein fibrillarin, transient polyclonal B-cell activation, hyperimmunoglobulinemia, and systemic immune-complex (IC) deposits. In order to study the short- and long-term effects of treatment with immunomodulating agents on the disease parameters in HgAI, groups of B10.S (H-2s) mice were given 6mg HgCl2/l drinking water for 22 weeks. Three weeks initial treatment with cyclosporin A (CyA), a high dose of tacrolimus (HD tacrolimus), or anti-CD4 monoclonal antibody (a-CD4) inhibited induction of ANoA and IC deposit by Hg. This effect persisted for the subsequent 19 weeks when the mice were only treated with Hg. Initial treatment with anti-IL-4 monoclonal antibody (a-IL-4) for 3 weeks inhibited induction of IgE and IC deposits by Hg, but not ANoA. However, subsequent treatment with Hg without a-IL-4 for 19 weeks induced IC deposits. The T-cell modulating agents aggravated some of the HgAI disease parameters: a-CD4 stimulated the polyclonal B-cell activation, a-IL-4 increased the IgG antichromatin antibody response, and a low dose of tacrolimus (LD tacrolimus) enhanced the ANoA, the polyclonal B-cell activation, and the IC deposits. We conclude that a short initial treatment with a-CD4 or CyA efficiently protects against induction of systemic autoimmunity for an extended period of time. However, some of the T-cell modulating agents, especially a low dose of tacrolimus, aggravate autoimmune manifestations not only during ongoing treatment, but also after treatment with these agents has ceased.

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MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Havarinasab, Said,1964-Linköpings universitet,Hälsouniversitetet,Molekylär och immunologisk patologi(Swepub:liu)saiha18 (författare)
Hultman, Per,1957-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Molekylär och immunologisk patologi,Klinisk patologi och klinisk genetik(Swepub:liu)perhu66 (författare)
Linköpings universitetHälsouniversitetet (creator_code:org_t)

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Ingår i:Toxicology: Elsevier BV196:3, s. 197-2090300-483X1879-3185

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Av författaren/redakt...: Mellergård, Joha ...; Havarinasab, Sai ...; Hultman, Per, 19 ...

Artiklar i publikationen: Toxicology

Av lärosätet: Linköpings universitet

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