Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations

Reis, MargaretaLund University,Lunds universitet,Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine (author)

Compliance with SSRI medication during 6 months of treatment for major depression : an evaluation by determination of repeated serum drug concentrations

Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood.Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements.Result: 9.4% of the per-protocol population in the trial (n=96) were in either hidden total (n=4) or hidden partial (n=5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified.

Åberg-Wistedt, AnnaKarolinska Institute, Department of Psychiatry, Stockholm, Sweden (author)
Ågren, HansKarolinska Institute, Neurote Department, Division of Psychiatry, Huddinge, Sweden (author)
Åkerblad, Ann-CharlotteDepartment of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden (author)
Bengtsson, Finn,1956-Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet(Swepub:liu)finbe20 (author)
Linköpings universitetKlinisk farmakologi (creator_code:org_t)

In:Journal of Affective Disorders: Elsevier BV82:3, s. 443-4460165-03271573-2517

By the author/editor: Reis, Margareta; Åberg-Wistedt, A ...; Ågren, Hans; Åkerblad, Ann-Ch ...; Bengtsson, Finn, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

By the university: Linköping University; Lund University; Karolinska Institutet

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