p53 status: an indicator for the effect of preoperative radiotherapy of rectal cancer.

p53 status : an indicator for the effect of preoperative radiotherapy of rectal cancer.

BACKGROUND: Rectal carcinoma is a common malignancy, with a history of high local recurrence rates following surgery. In recent years. preoperative radiotherapy and refined surgical technique have improved local control rates.AIM: To investigate the relationship between expression of nuclear p53 protein and the outcome in rectal carcinoma, with and without short-term preoperative radiotherapy.MATERIAL: Specimens from 163 patients from the Southeast Swedish Health Care region included in the Swedish rectal cancer trial between 1987-1990.METHOD: New sections from the paraffin blocks of the preoperative biopsy and the surgical specimen were examined immunohistochemically using a p53 antibody (PAb 1801).RESULT: Expression of nuclear p53 protein was seen in 41% of the tumours. The p53 negative patients treated with preoperative radiotherapy had a significant reduction of local failure compared with the non-irradiated p53 negative patients (P = 0.0008). In contrast, p53 positive patients showed no benefit from preoperative radiotherapy. The interaction between p53 status and the benefit of radiotherapy was statistically significant (P = 0.018).CONCLUSION: Expression of nuclear p53 protein in rectal carcinoma seems to be a significant predictive factor for local treatment failure after preoperative radiotherapy. Further investigations are necessary to select patients for preoperative treatment based on analysis of the preoperative biopsies.

Sun, Xiao-Feng,1959-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)xiasu45 (author)
Stål, Olle,1952-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)ollst87 (author)
Klintenberg, Claes,1945-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)clakl20 (author)
Sjödahl, Rune,1938-Linköpings universitet,Kirurgi,Hälsouniversitetet(Swepub:liu)runsj89 (author)
Nordenskjöld, Bo,1940-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)bono64 (author)
Linköpings universitetOnkologi (creator_code:org_t)

By the author/editor: Adell, Gunnar, 1 ...; Sun, Xiao-Feng, ...; Stål, Olle, 1952 ...; Klintenberg, Cla ...; Sjödahl, Rune, 1 ...; Nordenskjöld, Bo ...

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