SwePub
Sök i LIBRIS databas

  Extended search

L773:1432 1998 OR L773:0301 0449
 

Search: L773:1432 1998 OR L773:0301 0449 > (2000-2004) > Evaluation of the n...

  • Borg, HenrikLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine (author)

Evaluation of the new ADA and WHO criteria for classification of diabetes mellitus in young adult people (15-34 yrs) in the Diabetes Incidence Study in Sweden (DISS)

  • Article/chapterEnglish2003

Publisher, publication year, extent ...

  • Springer Science and Business Media LLC,2003
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-24903
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-24903URI
  • https://doi.org/10.1007/s00125-002-1021-4DOI
  • https://lup.lub.lu.se/record/114340URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211301URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:19113962URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims/hypothesis. We aimed to evaluate how an aetiology-based classification, as recommended in the ADA and WHO guidelines for classification of diabetes mellitus, matches clinical judgement in the Diabetes Incidence Study in Sweden (DISS), a study covering incident cases of diabetic patients aged 15 to 34 years. Methods. During a 1-year period (1998), blood samples were taken at diagnosis and 4 months (median) thereafter. Patients were classified according to clinical judgement by the reporting physicians and assessments of islet antibodies (ICA, GADA, and IA-2A) and plasma C-peptide. Results. In 1998, 422 patients were registered in DISS. Among the 313 patients participating in the follow-up, most with clinical Type 1 diabetes (185/218, 85%, 95% CI 79-89%) were islet antibody positive (ab+) at diagnosis. In addition, 14 out of 58 (24%, 14-37%) with clinical Type 2 diabetes and 21 out of 37 (57%, 40-73%) with unclassifiable diabetes were antibody positive at diagnosis. Further to this, 4 out of 33 (12%, 3-28%) were antibody negative with clinical Type 1 diabetes and 4 out of 44 (9%, 3-22%) with Type 2 had converted to antibody positive at follow-up. Among those who were constantly antibody negative, 10 out of 29 (34%, 18-54%) with clinical Type 1 and 1 out of 16 (6%, 0-30%) with unclassifiable diabetes had fasting plasma C-peptide concentrations below the normal range (<0.25 nmol/l) at follow-up. Conclusion/interpretation. Most young adults with clinical Type 1 diabetes (199/218, 91%) had objective Type 1 (ab+ at diagnosis/follow-up and/or low fasting plasma C-peptide concentrations at follow-up), as did one third (18/58, 31%) with clinical Type 2 diabetes and more than half (22/37, 59%) with unclassifiable diabetes. About 10% of those who were antibody negative converted to antibody positive. Our study underlines that a classification considering aetiology is superior to clinical judgement.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Björk, E (author)
  • Bolinder, JKarolinska Institutet (author)
  • Eriksson, JWUppsala universitet,Endokrin diabetes och metabolism (author)
  • Nyström, L (author)
  • Jeppsson, Jan-OlofLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-jje (author)
  • Sundkvist, GöranLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-gsu (author)
  • Arnqvist, Hans,1943-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Cellbiologi,EMT-endo(Swepub:liu)hanar64 (author)
  • Medicin, LundSektion II (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer Science and Business Media LLC46:2, s. 173-1810012-186X1432-0428

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view