Association of breast cancer progression with a vitamin D receptor gene polymorphism

Lundin, Anna-CarinLinköpings universitet,Cellbiologi,Hälsouniversitetet (author)

The vitamin D3 receptor gene (VDR) contains a TaqI RFLP that is associated with increased VDR mRNA stability, increased serum levels of 1α,25-dihydroxyvitamin D3 (1,25-D3), and decreased risk for prostate cancer. Determination of the TaqI genotype, in a group of young women with breast cancer (n = 111; age, <37 years) and a control population (n = 130), revealed no overall association to risk for breast cancer. However, patients without TaqI site (TT genotype) showed a significantly increased risk for lymph node metastasis (relative risk, 1.8, 95% confidence interval, 1.3- 2.6). Furthermore, a tendency toward an increased survival was found among estrogen receptor-positive, tamoxifen-treated patients who were homozygous for the TaqI site (P = 0.075). We conclude that polymorphism in the VDR gene may influence tumor progression and tamoxifen treatment response in early- onset breast carcinomas.

Söderkvist, Peter,1953-Linköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)petso43 (author)
Eriksson, BirgittaLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)birer83 (author)
Bergman-Jungeström, Malin,1967-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)malbe59 (author)
Wingren, Sten,1950-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)stewi96 (author)
Linköpings universitetCellbiologi (creator_code:org_t)

By the author/editor: Lundin, Anna-Car ...; Söderkvist, Pete ...; Eriksson, Birgit ...; Bergman-Jungestr ...; Wingren, Sten, 1 ...

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