Sökning: L773:1938 1964 OR L773:1938 1956 >
Activation of Rac2 ...
Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils
-
- Forsberg, Maria, 1973- (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
-
- Druid, Pia, 1956- (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
-
- Zheng, Limin, 1964- (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
-
visa fler...
-
- Stendahl, Olle, 1946- (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
-
- Särndahl, Eva, 1963- (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
-
visa färre...
-
(creator_code:org_t)
- 2003-07-01
- 2003
- Engelska.
-
Ingår i: Journal of Leukocyte Biology. - : Oxford University Press (OUP). - 0741-5400 .- 1938-3673. ; 74:4, s. 611-619
- Relaterad länk:
-
https://jlb.onlineli...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Phagocytosis is a complex process engaging a concerted action of signal-transduction cascades that leads to ingestion, subsequent phagolysosome fusion, and oxidative activation. We have previously shown that in human neutrophils, C3bi-mediated phagocytosis elicits a significant oxidative response, suggesting that activation of the small GTPase Rac is involved in this process. This is contradictory to macrophages, where only Fc receptor for immunoglobulin G (FcγR)-mediated activation is Rac-dependent. The present study shows that engagement of the complement receptor 3 (CR3) and FcγR and CR3- and FcγR-mediated phagocytosis activates Rac, as well as Cdc42. Furthermore, following receptor-engagement of the CR3 or FcγRs, a downstream target of these small GTPases, p21-activated kinase, becomes phosphorylated, and Rac2 is translocated to the membrane fraction. Using the methyltransferase inhibitors N-acetyl-S-farnesyl-L-cysteine and N-acetyl-S-geranylgeranyl-L-cysteine, we found that the phagocytic uptake of bacteria was not Rac2- or Cdc42-dependent, whereas the oxidative activation was decreased. In conclusion, our results indicate that in neutrophils, Rac2 and Cdc42 are involved in FcR- and CR3-induced activation and for properly functioning signal transduction involved in the generation of oxygen radicals.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Forsberg, Maria, ...
-
Druid, Pia, 1956 ...
-
Zheng, Limin, 19 ...
-
Stendahl, Olle, ...
-
Särndahl, Eva, 1 ...
- Artiklar i publikationen
-
Journal of Leuko ...
- Av lärosätet
-
Linköpings universitet