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Apolipoprotein A-1-...
Apolipoprotein A-1-derived amyloid in atherosclerotic plaques of the human aorta
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- Mucchiano, Gerd (författare)
- Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet
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- Häggqvist, Bo, 1962- (författare)
- Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet
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- Sletten, Knut (författare)
- Department of Biochemistry and Biotechnology Center of Oslo, University of Oslo, Norway
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- Westermark, Per (författare)
- Department of Genetics and Pathology, Uppsala University, Sweden
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: Journal of Pathology. - 0022-3417 .- 1096-9896. ; 193:2, s. 270-275
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Previous studies have shown that the amyloid localized to the aortic intima may be a biochemical entity different from other forms of localized amyloid. The amyloid fibril protein in one patient studied consisted of an N-terminal fragment of apolipoprotein A-1 (apo A-1). Since this patient was later shown to carry a missense mutation in the apo A-1 gene, leading to a deletion at position 107 of the mature protein, the question remained whether wild-type apo A-1 is amyloidogenic. In autopsy specimens from the thoracic aorta from 69 individuals, intimal atherosclerotic plaque-related amyloid was present in 11 cases (16%) and amyloid outside plaques in 37 cases (54%). The immunoreactivity of amyloid localized to the aortic intima was evaluated with the aid of antisera against N-terminal segments of apo A-1. The amyloid in association with atherosclerotic plaques was positively labelled by immunohistochemistry. The amyloid fibril protein from one patient, previously shown not to carry any mutation in the apo A-1 gene, was purified and shown by amino acid sequence analysis to be of apo A-1 nature. The result shows that wild-type apo A-1 is amyloidogenic and gives rise to a common localized form of amyloid associated with atherosclerosis.
Nyckelord
- amyloid
- aorta
- intima
- apolipoprotein A-1
- atherosclerosis
- immunocytochemistry
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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