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Lower serum levels ...
Lower serum levels of beta-carotene in Lithuanian men are accompanied by higher urinary excretion of the oxidative DNA adduct, 8-hydroxydeoxyguanosine : The LiVicordia study.
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- Kristenson, Margareta, 1950- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Socialmedicin och folkhälsovetenskap,Socialmed FHVC
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Kucinskiené, Zita (author)
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- Schäfer-Elinder, Liselotte (author)
- Karolinska Institutet
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- Leanderson, Per, 1958- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Yrkes- och miljömedicin,Yrkes- och miljömedicinskt centrum
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- Tagesson, Christer, 1948- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Yrkes- och miljömedicin,Yrkes- och miljömedicinskt centrum
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Nutrition. - 0899-9007 .- 1873-1244. ; 19:1, s. 11-15
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVE: In 1995, middle-aged Lithuanian men had a four-fold higher risk than Swedish men of dying from coronary heart disease. The cross-sectional LiVicordia study had reported significantly lower levels of the lipid-soluble antioxidants lycopene, ▀-carotene, and ?-tocopherol among Lithuanian men than among Swedish men. We examined whether there were differences in urinary 8-hydroxydeoxyguanosine (8OHdG), a marker of oxidative stress, between these groups of men. METHODS: Using automated coupled column high-performance liquid chromatography with electrochemical detection, we examined 50-y-old men randomly sampled from Link÷ping, Sweden (n = 99) and Vilnius, Lithuania (n = 109) with regard to urinary concentrations of 8-OHdG. RESULTS: Levels of 8-OHdG were higher in the Lithuanian men than in the Swedish men (20.9 ▒ 0.91 versus 14.9 ▒ 0.75 nM/L, P < 0.001), and this difference was evident in smokers (P < 0.01) and non-smokers (P < 0.001). Serum levels of a- and ▀-carotene were inversely correlated to urinary 8-OHdG levels (P < 0.05 in both cases). Habitual smoking and low levels of ▀-carotene contributed significantly to higher oxidative DNA damage expressed as urinary 8-OHdG. CONCLUSIONS: These findings indicate that increased urinary 8-OHdG levels accompany lower serum levels of antioxidants in Lithuanian men. They supported previous suggestions that increased oxidative stress may be one factor behind the higher mortality in Lithuanian men. ⌐ Elsevier Science Inc. 2003.
Keyword
- SOCIAL SCIENCES
- SAMHÄLLSVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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