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Glutathione S-trans...
Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals
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Buzio, L (författare)
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De Palma, G (författare)
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Mozzoni, p (författare)
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- Tondel, Martin, 1962- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Yrkes- och miljömedicin,Yrkes- och miljömedicinskt centrum
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Buzio, C (författare)
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Franchini, I (författare)
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- Axelson, Olav, 1937- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Yrkes- och miljömedicin,Yrkes- och miljömedicinskt centrum
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Mutti, A (författare)
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(creator_code:org_t)
- BMJ, 2003
- 2003
- Engelska.
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Ingår i: Occupational and Environmental Medicine. - : BMJ. - 1351-0711 .- 1470-7926. ; 60:10, s. 789-793
- Relaterad länk:
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https://oem.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims: To investigate the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in renal cell cancer (RCC). Methods: One hundred patients with RCC and 200 outpatient controls were enrolled at Parma University Hospital. The polymorphisms of glutathione S-transferase M1-1 (GSTM1) and T1-1 (GSTT1) were investigated by PCR, occupational history was collected by a structured questionnaire. Results: Subjects with GSTM1 present genotype showed higher risks for RCC, compared to GSTM1 null subjects, if exposed to metals (OR 2.73, 95% CI 0.91 to 8.22 v 1.14, 95% CI 0.46 to 2.82) or pesticides (OR 3.46, 95% CI 1.12 to 10.74 v 1.59, 95% CI 0.48 to 5.34). The GSTT1 present genotype also enhanced the risk (about twofold) of RCC among subjects exposed to solvents and pesticides, compared with those GSTT1 null. Conclusions: Results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.
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- MEDICINE
- MEDICIN
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- art (ämneskategori)
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Buzio, L
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De Palma, G
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Mozzoni, p
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Tondel, Martin, ...
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Buzio, C
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Franchini, I
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Axelson, Olav, 1 ...
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Mutti, A
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- Artiklar i publikationen
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Occupational and ...
- Av lärosätet
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Linköpings universitet