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The expression of a...
The expression of adhesion molecules in muscle biopsies : the LFA-1/VLA-4 ratio in polymyositis
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- Lindvall, Björn, 1952- (author)
- Linköpings universitet,Neurologi,Hälsouniversitetet
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- Dahlbom, K. (author)
- Department of Neurology, County Hospital in Örebro, Sweden
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- Henriksson, Karl-Gösta, 1928- (author)
- Linköpings universitet,Neurologi,Hälsouniversitetet
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- Srinivas, U. (author)
- Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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- Ernerudh, Jan, 1952- (author)
- Linköpings universitet,Neurologi,Klinisk kemi,Hälsouniversitetet
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(creator_code:org_t)
- 2003-02-12
- 2003
- English.
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In: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 107:2, s. 134-141
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives– The expression of three pairs of adhesion receptors and ligands was examined in 22 consecutive muscle biopsies showing morphological signs of inflammation.Material and methods– The following groups were studied: patients with polymyositis (PM) (n=7), patients with myositis that did not fulfil criteria for PM, i.e. suspected PM (n=5), patients with other diseases, with no clinical signs of inflammatory myopathy (n=6), and a small group of non-PM inflammatory myopathies (n=4). The endothelial expression of ICAM-1, VCAM-1 and E-selectin was evaluated, as was the cellular expression of LFA-1, VLA-4 and SLex. In addition, the expression of MHC class I and II was studied.Results– The ratio between the number of cells expressing LFA-1 and VLA-4 showed significant differences between the groups, with the lowest values in PM.Conclusion– The LFA-1/VLA-4 ratio should be suitable for diagnostic purposes. Our findings also indicate that the VLA-4/VCAM-1 system is important for chronic T cell inflammation in muscle, in line with findings in other “hidden” organs like joints and the central nervous system.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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