One year of Neisseria gonorrhoeae isolates in Sweden: the prevalence study of antibiotic susceptibility shows relation to the geographic area of exposure

One year of Neisseria gonorrhoeae isolates in Sweden : the prevalence study of antibiotic susceptibility shows relation to the geographic area of exposure

The aim of this study was to compare epidemiological data with antibiotic susceptibility patterns, so as to characterize the risk of infection with a highly resistant Neisseria gonorrhoeae strain. N. gonorrhoeae strains isolated in Sweden from February 1998 through January 1999 were tested for antibiotic susceptibility. Epidemiological data were received from each clinician reporting a case of gonorrhoea and these data were linked to the N. gonorrhoeae strains. A total of 348 N. gonorrhoeae isolates, representing 89% of all Swedish cases diagnosed during the 12-month period, were tested for antibiotic susceptibility. Of all isolates, 24% were β-lactamase-producing, and 18% had decreased susceptibility to ciprofloxacin (MIC>0.064 mg/l). All isolates were fully susceptible to ceftriaxone and spectinomycin. More than 99% of the isolates were fully susceptible to azithromycin. The antibiotic susceptibility varied with the places where patients were exposed to infection. When exposed in Asia, 63% of the isolates showed reduced susceptibility to ciprofloxacin, compared with 0-8.5% of the isolates from patients exposed in other places (RR=8.5, P<0.001). Ciprofloxacin cannot be recommended as the first choice of treatment if the place of exposure was in Asia.

Unemo, Magnus,1970-Department of Clinical Microbiology and Immunology, Örebro Medical Centre Hospital, Örebro, Sweden(Swepub:liu)magun79 (author)
Olcén, Per,1943-Department of Clinical Microbiology and Immunology, Örebro Medical Centre Hospital, Örebro, Sweden(Swepub:liu)perol69 (author)
Giesecke, JohanKarolinska Institutet (author)
Fredlund, Hans,1952-Department of Clinical Microbiology and Immunology, Örebro Medical Centre Hospital, Örebro, Sweden and Unit for Infectious Disease Control, Department of Clinical Microbiology and Immunology, Örebro Medical Centre Hospital, Örebro, Sweden(Swepub:liu)hanfr82 (author)
Karolinska InstitutetDepartment of Clinical Microbiology and Immunology, Örebro Medical Centre Hospital, Örebro, Sweden (creator_code:org_t)

In:International Journal of STD and AIDS (London): SAGE Publications13:2, s. 109-1140956-46241758-1052

By the author/editor: Berglund, Torste ...; Unemo, Magnus, 1 ...; Olcén, Per, 1943 ...; Giesecke, Johan; Fredlund, Hans, ...

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