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Effects of rosuvast...
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Olsson, Anders,1940-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Internmedicin,EMK-endokrin
(author)
Effects of rosuvastatin and atorvastatin compared over 52 weeks of treatment in patients with hypercholesterolemia
- Article/chapterEnglish2002
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Elsevier BV,2002
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LIBRIS-ID:oai:DiVA.org:liu-27087
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-27087URI
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https://doi.org/10.1067/mhj.2002.128049DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Despite the demonstrated benefits of low-density lipoprotein cholesterol (LDL-C) reduction in reducing the risk of coronary heart disease, many patients receiving lipid-lowering therapy fail to achieve LDL-C goals. We compared the effects of rosuvastatin and atorvastatin in reducing LDL-C and achieving LDL-C goals in patients with primary hypercholesterolemia. Methods and Results: In this 52-week, randomized, double-blind, multicenter trial (4522IL/0026), 412 patients with LDL-C 160 to <250 mg/dL received a 5-mg dose of rosuvastatin (n = 138), a 10-mg dose of rosuvastatin (n = 134), or a 10-mg dose of atorvastatin (n = 140) for 12 weeks, during the following 40 weeks, dosages could be sequentially doubled up to 80 mg if National Cholesterol Education Program Adult Treatment Panel II (ATP-II) LDL-C goals were not achieved. At 12 weeks, 5- and 10-mg doses of rosuvastatin were associated with significantly greater LDL-C reductions than 10-mg doses of atorvastatin (46% and 50% vs 39%, both P < .001). At 12 weeks, both rosuvastatin dosages brought more patients to within ATP-II and European LDL-C goals than atorvastatin (86% and 89% vs 73% and 75%, and 86% vs 55%, respectively). At 52 weeks, compared with atorvastatin, both initial rosuvastatin treatment groups significantly reduced LDL-C (47% and 53% vs 44%, P < .05 and P < .001). Overall, more patients in the initial rosuvastatin 10-mg group achieved their ATP-II LDL-C goal than those in the initial atorvastatin 10-mg group (98% vs 87%), with 82% of patients treated with rosuvastatin achieving their goal at the 10-mg starting dosage without the need for titration, compared with 59% of patients treated with atorvastatin. Both treatments were well tolerated over 52 weeks. Conclusion: Compared with atorvastatin, rosuvastatin produced greater reductions in LDL-C, which may offer advantages in LDL-C goal attainment over existing lipid-lowering therapies.
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Istad, Helge
(author)
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Luurila, Olavi
(author)
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Ose, Leiv
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Stender, Steen
(author)
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Tuomilehto, Jaakko
(author)
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Wiklund, Olov
(author)
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Southworth, Harry
(author)
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Pears, John
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Wilpshaar, J W
(author)
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Linköpings universitetHälsouniversitetet
(creator_code:org_t)
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In:American Heart Journal: Elsevier BV144:6, s. 1044-10510002-87031097-6744
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Olsson, Anders, ...
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Istad, Helge
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Luurila, Olavi
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Ose, Leiv
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Stender, Steen
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Tuomilehto, Jaak ...
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Wiklund, Olov
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Southworth, Harr ...
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Pears, John
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Wilpshaar, J W
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Linköping University