Search: WFRF:(Waters M.)
> (2000-2004) >
Effects of atorvast...
Effects of atorvastatin on stroke in patients with unstable angina or non-Q-wave myocardial infarction : A myocardial ischemia reduction with aggressive cholesterol lowering (MIRACL) substudy
- Article/chapterEnglish2002
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:liu-27088
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-27088URI
-
https://doi.org/10.1161/01.CIR.0000031568.40630.1CDOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background - This report describes the effect of intensive cholesterol lowering with atorvastatin on the incidence of nonfatal stroke, a secondary end point, in a randomized, placebo-controlled trial of patients with unstable angina or non-Q-wave myocardial infarction. The primary end point, a composite of death, nonfatal myocardial infarction, resuscitated cardiac arrest, or recurrent symptomatic myocardial ischemia with objective evidence requiring emergency rehospitalization, was reduced from 17.4% in the placebo group to 14.8% in the atorvastatin group over the 16 weeks of the trial (P=0.048). Methods and Results - Strokes were adjudicated by a blinded end-point committee using standard clinical and imaging criteria. The outcomes of nonfatal stroke and fatal plus nonfatal stroke were analyzed by time to first occurrence during the 16-week trial. Of 38 events (in 36 patients) adjudicated as fatal or nonfatal strokes, 3 were classified as hemorrhagic, one as embolic, and 29 as thrombotic or embolic, 5 could not be categorized. Nonfatal stroke occurred in 9 patients in the atorvastatin group and 22 in the placebo group (relative risk, 0.40, 95% confidence intervals, 0.19 to 0.88, P=0.02). Fatal or nonfatal stroke occurred in 12 atorvastatin patients and 24 placebo patients (relative risk, 0.49, 95% confidence intervals, 0.24 to 0.98, P=0.04). All 3 hemorrhagic strokes occurred in the placebo group. Conclusion - Intensive cholesterol lowering with atorvastatin over 16 weeks in patients with acute coronary syndromes reduced the overall stroke rate by half and did not cause hemorrhagic stroke. These findings need to be confirmed in future trials.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Schwartz, GG
(author)
-
Olsson, Anders,1940-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Internmedicin,EMK-endokrin(Swepub:liu)andol21
(author)
-
Zeiher, A
(author)
-
Oliver, MF
(author)
-
Ganz, P
(author)
-
Ezekowitz, M
(author)
-
Chaitman, BR
(author)
-
Leslie, SJ
(author)
-
Stern, T
(author)
-
Linköpings universitetHälsouniversitetet
(creator_code:org_t)
Related titles
-
In:Circulation106:13, s. 1690-16950009-73221524-4539
Internet link
Find in a library
To the university's database
- By the author/editor
-
Waters, DD
-
Schwartz, GG
-
Olsson, Anders, ...
-
Zeiher, A
-
Oliver, MF
-
Ganz, P
-
show more...
-
Ezekowitz, M
-
Chaitman, BR
-
Leslie, SJ
-
Stern, T
-
show less...
- Articles in the publication
-
Circulation
- By the university
-
Linköping University