Galantamine demonstrates efficacy and safety in elderly patients with Alzheimer disease

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: L773:1546 4156 > Galantamine demonst...

Marcusson, Jan,1958-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Geriatrik,Geriatrik-LAH (författare)

Galantamine demonstrates efficacy and safety in elderly patients with Alzheimer disease

Artikel/kapitelEngelska2003

Förlag, utgivningsår, omfång ...

Ovid Technologies (Wolters Kluwer Health),2003
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-27880
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-27880URI
https://doi.org/10.1097/00002093-200307003-00005DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Alzheimer disease (AD) treatment guidelines state that cholinergic agents are not cost-effective in patients with more severe disease. Because many physicians may deem an older patient unlikely to respond to treatment, older AD patients may remain untreated. Galantamine (Reminyl), a novel cholinergic agent, is effective in mild to moderate AD. This post hoc analysis of pooled phase III galantamine clinical trials was designed to assess whether older (=80 years) and younger (=79 years) AD patients experience similar benefits with galantamine based on changes in the ADAS-cog and CIBIC-plus. Mean ADAS-cog scores for older patients treated with galantamine 24 mg/day significantly improved versus baseline and versus placebo at month 3. Cognitive improvement was maintained versus placebo at month 6, the ADAS-cog score for placebo patients dropped below baseline at month 6. Change in CIBIC-plus for galantamine was significantly different from placebo at months 5 to 6. Mean ADAS-cog score in older patients taking galantamine for 12 months remained above baseline. The score for patients taking placebo for 6 months before switching to galantamine did not differ significantly from baseline at 12 months but was lower than in patients receiving galantamine for 12 months. Incidence of adverse events in patients > 80 years was similar to that in the overall study population. Galantamine maintained cognitive and global function in patients > 80 years with mild to moderate AD for at least 5 to 6 months and cognitive efficacy for 12 months. Prescribing approved therapies such as galantamine for older patients with AD is recommended.

Ämnesord och genrebeteckningar

MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Bullock, Roger (författare)
Gauthier, Serge (författare)
Kurz, Alexander (författare)
Schwalen, Susanne (författare)
Linköpings universitetHälsouniversitetet (creator_code:org_t)

Sammanhörande titlar

Ingår i:Alzheimer Disease and Associated Disorders: Ovid Technologies (Wolters Kluwer Health)17:SUPPL. 30893-03411546-4156

Internetlänk

Hitta via bibliotek

Alzheimer Disease and Associated Disorders (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Marcusson, Jan, ...; Bullock, Roger; Gauthier, Serge; Kurz, Alexander; Schwalen, Susann ...

Artiklar i publikationen: Alzheimer Diseas ...

Av lärosätet: Linköpings universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se