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Cross-talk between ...
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Asplund Persson, Anna,1966-Linköpings universitet,Farmakologi,Hälsouniversitetet
(författare)
Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets
- Artikel/kapitelEngelska2005
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Elsevier BV,2005
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:liu-30677
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-30677URI
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https://doi.org/10.1016/j.ejphar.2005.05.019DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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We examined the interplay between adenosine and the nitric oxide (NO)-containing oxatriazole derivative GEA 3175 in human platelets. The importance of cyclic guanosine 3′5′-monophosphate (cGMP)-inhibited phosphodiesterases (PDEs) was elucidated by treating the platelets with adenosine combined with either GEA 3175 or the PDE3-inhibitor milrinone. The drug combinations provoked similar cyclic adenosine 3′5′-monophosphate (cAMP) responses. On the contrary, cGMP levels were increased only in GEA 3175-treated platelets. Both drug combinations reduced P-selectin exposure, platelet adhesion and fibrinogen-binding. However, adenosine together with GEA 3175 was more effective in inhibiting platelet aggregation and ATP release. Thrombin-induced rises in cytosolic Ca2+ were suppressed by the two drug combinations. Adenosine administered with GEA 3175 was, however, more effective in reducing Ca2+ influx.In conclusion, the interaction between adenosine and GEA 3175 involves cGMP-mediated inhibition of PDE3. The results also imply that inhibition of Ca2+ influx represent another cGMP-specific mechanism that enhances the effect of adenosine.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zalavary, StefanLinköpings universitet,Hälsouniversitetet(Swepub:liu)steza78
(författare)
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Lindström, Eva,1961-Linköpings universitet,Farmakologi,Hälsouniversitetet(Swepub:liu)evali73
(författare)
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Whiss, Per A,1966-Linköpings universitet,Farmakologi,Hälsouniversitetet(Swepub:liu)perwh53
(författare)
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Bengtsson, Torbjörn,1955-Linköpings universitet,Farmakologi,Hälsouniversitetet(Swepub:liu)torbe62
(författare)
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Grenegård, Magnus,1963-Linköpings universitet,Farmakologi,Hälsouniversitetet(Swepub:liu)maggr06
(författare)
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Linköpings universitetFarmakologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Pharmacology: Elsevier BV517:3, s. 149-1570014-29991879-0712
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