Search: id:"swepub:oai:DiVA.org:liu-31124" >
Polymorphism in the...
-
Bergman, Malin,1967-Linköpings universitet,Onkologi,Hälsouniversitetet
(author)
Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women
- Article/chapterEnglish2005
Publisher, publication year, extent ...
-
2005-05-10
-
Springer Science and Business Media LLC,2005
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:liu-31124
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-31124URI
-
https://doi.org/10.1007/s00432-004-0663-7DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Purpose: Manganese superoxide dismutase (MnSOD) is one of the major enzymes implicated in the cellular defence against reactive oxygen species. Low expression of MnSOD has been observed in different cancer tissues and several reports have shown that overexpression of MnSOD inhibits growth in various human cancer cells. These observations suggest that MnSOD is involved in carcinogenesis. A polymorphism (Ala-9Val) in the mitochondrial targeting sequence (MTS) of the MnSOD gene has been proposed to affect protein localization and thereby influence cellular defence against superoxide radicals.Methods: In the present case-control study, including 118 early onset breast cancer patients (≤36 years) and 174 age-matched controls, the MTS polymorphism and loss of heterozygosity (LOH) in the locus of MnSOD were analysed.Results: We found that individuals with MnSODVal/Val and MnSODVal/Ala genotypes showed an increased risk of breast cancer (OR, 2.7; 95% CI, 2.2–5.5, p=0.01, OR, 3.0; 95%CI, 1.4–6.5, p=0.002). Moreover, 45% of the informative cases expressed allelic loss at the chromosomal locus of the MnSOD gene. No correlation was found between LOH and the genotype.Conclusion: The present study suggests that MnSOD may be implicated in breast carcinogenesis in young women.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ahnström, Marie,1976-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)marah62
(author)
-
Palmebäck Wegman, Pia,1964-Linköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)piapa49
(author)
-
Wingren, Sten,1950-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)stewi96
(author)
-
Linköpings universitetOnkologi
(creator_code:org_t)
Related titles
-
In:Journal of Cancer Research and Clinical Oncology: Springer Science and Business Media LLC131:7, s. 439-4440171-52161432-1335
Internet link
Find in a library
To the university's database