Search: WFRF:(Rydén Göran)
> (2005-2009) >
Pathology parameter...
Pathology parameters and adjuvant tamoxifen response in a randomised premenopausal breast cancer trial
-
- Jirström, Karin (author)
- Lund University,Lunds universitet,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Pathology Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden
-
- Rydén, Lisa (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Pathology Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden
-
- Anagnostaki, L (author)
- Division of Pathology Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden
-
show more...
-
- Nordenskjöld, Bo, 1940- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
-
- Stål, Olle, 1952- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
-
- Thorstenson, S (author)
- Department of Pathology and Cytology, Kalmar County Hospital, Kalmar, Sweden
-
- Chebil, G (author)
- Department of Pathology, Helsingborg Hospital, Helsingborg, Sweden
-
- Jönsson, P-E (author)
- Department of Surgery, Helsingborg Hospital
-
- Fernö, Mårten (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, Lund University Hospital, Lund, Sweden
-
- Landberg, Göran (author)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Division of Pathology Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden
-
show less...
-
(creator_code:org_t)
- BMJ, 2005
- 2005
- English.
-
In: Journal of Clinical Pathology. - : BMJ. - 0021-9746 .- 1472-4146. ; 58:11, s. 1135-1142
- Related links:
-
https://jcp.bmj.com/...
-
show more...
-
https://portal.resea... (primary) (free)
-
http://www.ncbi.nlm.... (free)
-
http://dx.doi.org/10... (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Background: Subgroups of breast cancer that have an impaired response to endocrine treatment, despite hormone receptor positivity, are still poorly defined. Breast cancer can be subdivided according to standard pathological parameters including histological type, grade, and assessment of proliferation. These parameters are the net result of combinations of genetic alterations effecting tumour behaviour and could potentially reflect subtypes that respond differently to endocrine treatment.Aims: To investigate the usefulness of these parameters as predictors of the response to tamoxifen in premenopausal women with breast cancer.Materials/methods: Clinically established pathological parameters were assessed and related to the tamoxifen response in 500 available tumour specimens from 564 premenopausal patients with breast cancer randomised to either two years of tamoxifen or no treatment with 14 years of follow up. Proliferation was further evaluated by immunohistochemical Ki-67 expression.Results: Oestrogen receptor positive ductal carcinomas responded as expected to tamoxifen, whereas the difference in recurrence free survival between control and tamoxifen treated patients was less apparent in the relatively few lobular carcinomas. For histological grade, there was no obvious difference in treatment response between the groups. The relation between proliferation and tamoxifen response seemed to be more complex, with a clear response in tumours with high and low proliferation, whereas tumours with intermediate proliferation defined by Ki-67 responded more poorly.Conclusions: Clinically established pathology parameters seem to mirror the endocrine treatment response and could potentially be valuable in future treatment decisions for patients with breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Jirström, Karin
-
Rydén, Lisa
-
Anagnostaki, L
-
Nordenskjöld, Bo ...
-
Stål, Olle, 1952 ...
-
Thorstenson, S
-
show more...
-
Chebil, G
-
Jönsson, P-E
-
Fernö, Mårten
-
Landberg, Göran
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Linköping University
-
Lund University