Phenotypic and genotypic characterization of prolyliminopeptidase-negative Neisseria gonorrhoeae isolates in Denmark.

In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (PIP)-negative Neisseria gonorrhoeae were phenotypically and genotypically characterized to investigate whether one or more PIP-negative strains are circulating in the Danish community. The profiles of these isolates were compared with those of three isolates from a recent outbreak of PIP-negative N. gonorrhoeae infection in the UK. Twenty-five of the Danish isolates and all three UK isolates had similar antibiograms and were designated serovar IB-4. Genotypic characterization by pulsed-field gel electrophoresis, porB1b gene sequencing, and opa-typing revealed that these isolates were indistinguishable or closely related. The results indicate that at least one PIP-negative N. gonorrhoeae strain is currently circulating in the Danish community, and this strain is indistinguishable from the one that caused an outbreak in the UK.

In:European Journal of Clinical Microbiology and Infectious Diseases: Springer Science and Business Media LLC24:4, s. 280-2830934-97231435-4373

By the author/editor: Fjeldsoe-Nielsen ...; Unemo, Magnus, 1 ...; Fredlund, Hans, ...; Hjorth, SV; Berthelsen, LM; Palmer, HM; show more...; Friis-Möller, A; show less...

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