Sökning: id:"swepub:oai:DiVA.org:liu-34881" >
Decreased plasma CX...
-
Sheikine, YKarolinska Institutet
(författare)
Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease
- Artikel/kapitelEngelska2006
Förlag, utgivningsår, omfång ...
-
Elsevier BV,2006
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-34881
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-34881URI
-
https://doi.org/10.1016/j.atherosclerosis.2005.11.025DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:1937288URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Objectives: To investigate for the first time whether the plasma CXCL16 concentration is altered in coronary artery disease (CAD) patients. Background: Accumulating evidence suggests that the novel chemokine/scavenger receptor CXCL16/SR-PSOX is involved in the development of atherosclerosis and CAD. Methods: Using ELISA we assessed the plasma CXCL16 concentration in 40 stable angina pectoris (SAP) patients, 17 unstable angina pectoris/non-ST-elevation myocardial infarction (UAP/non-STEMI) patients, 387 survivors of a first myocardial infarction (MI) and healthy control subjects (44 controls for SAP and UAP/non-STEMI patient groups and 387 controls for post-MI patients). Results: SAP patients exhibited significantly lower median CXCL16 levels (2111 pg/ml) than the corresponding control subjects (2678 pg/ml) (P = 0.0012). UAP/non-STEMI patients also appeared to have lower CXCL16 levels (2192 pg/ml) compared with controls (NS). Patients investigated 3 months after MI tended (P = 0.07) to have lower CXCL16 levels (2529 pg/ml) than the corresponding controls (2638 pg/ml). There were no significant correlations between CXCL16 levels and different measures of CAD severity determined by quantitative coronary angiography in post-MI patients. Neither patients nor controls exhibited significant correlations between CXCL16 levels and plasma lipoprotein fractions, inflammatory cytokines, C-reactive protein or numbers of inflammatory cells in peripheral blood. Conclusions: The finding that lower plasma CXCL16 concentration is associated with CAD might indicate a potential atheroprotective function of CXCL16. © 2005 Elsevier Ireland Ltd. All rights reserved.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Bang, CS
(författare)
-
Nilsson, Lennart,1971-Linköpings universitet,Institutionen för medicin och vård,Hälsouniversitetet(Swepub:liu)lenni29
(författare)
-
Samnegård, AKarolinska Institutet
(författare)
-
Hamsten, AKarolinska Institutet
(författare)
-
Jonasson, Lena,1956-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kardiologi,Kardiologiska kliniken(Swepub:liu)lenjo59
(författare)
-
Eriksson, PKarolinska Institutet
(författare)
-
Sirsjö, A
(författare)
-
Karolinska InstitutetInstitutionen för medicin och vård
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Atherosclerosis: Elsevier BV188:2, s. 462-4660021-91501879-1484
Internetlänk
Hitta via bibliotek
Till lärosätets databas