Late miscarriage and preterm birth after treatment with clindamycin: A randomised consent design study according to Zelen

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Larsson, Per-Göran,1953-Linköpings universitet,Hälsouniversitetet,Genus och medicin (författare)

Late miscarriage and preterm birth after treatment with clindamycin : A randomised consent design study according to Zelen

Artikel/kapitelEngelska2006

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Wiley,2006
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LIBRIS-ID:oai:DiVA.org:liu-35129
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-35129URI
https://doi.org/10.1111/j.1471-0528.2006.00946.xDOI

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Språk:engelska
Sammanfattning på:engelska

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Objective: To screen for bacterial vaginosis (BV) and to investigate the effect of treatment with vaginal clindamycin in order to observe the effect on late miscarriage and delivery prior to 37 completed weeks (primary outcome). Design: Randomised consent design for clinical trials according to Zelen. Setting: Southeast region of Sweden. Population: A total of 9025 women were screened in early pregnancy. Methods: A total of 819 women with a Nugent score of 6 and above were considered to have BV and treated according to Zelen allocation. The incidence of late miscarriage and spontaneous (noniatrogenic) preterm birth was assessed. Main outcome measures: Late miscarriage and spontaneous preterm delivery before 37 weeks. Results: Therapy with vaginal clindamycin had no significant impact on the incidence of spontaneous preterm delivery prior to 37 completed weeks, OR 0.90, 95% CI 0.40-2.02 (primary outcome variable). However, only 1 of 11 women in the treatment group versus 5 of 12 in the control group delivered prior to 33 completed weeks, OR 0.14, 95% CI 0.02-0.95. Treatment was associated with 32 days longer gestation for the 23 participants who had late miscarriage or spontaneous preterm birth (P= 0.024, Mann-Whitney U test) and significantly fewer infants had a birthweight below 2500 g (secondary outcome). A follow up of infants born preterm 4 years postnatally indicated that extending gestational age did not increase the number of sequelae. Conclusions: Clindamycin vaginal cream therapy was associated with significantly prolonged gestation and reduced cost of neonatal care in women with BV. Early screening for BV and treatment with clindamycin saved approximately €27 per woman. © RCOG 2006 BJOG An International Journal of Obstetrics and Gynaecology.

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MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Fåhraeus, Lars,1939-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Obstetrik och gynekologi,Kvinnokliniken i Linköping(Swepub:liu)larfa31 (författare)
Carlsson, Bodil,1949-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk mikrobiologi(Swepub:liu)bodca74 (författare)
Jakobsson, Tell,1951-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk mikrobiologi(Swepub:liu)telja07 (författare)
Forsum, Urban,1946-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk mikrobiologi(Swepub:liu)urbfo84 (författare)
Linköpings universitetHälsouniversitetet (creator_code:org_t)

Sammanhörande titlar

Ingår i:British Journal of Obstetrics and Gynecology: Wiley113:6, s. 629-6371470-03281471-0528

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British Journal of Obstetrics and Gynecology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Larsson, Per-Gör ...; Fåhraeus, Lars, ...; Carlsson, Bodil, ...; Jakobsson, Tell, ...; Forsum, Urban, 1 ...

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