In vitro Th2 deviation of myelin-specific peripheral blood lymphocytes from patients with multiple sclerosis

Hallin, Elisabeth,1980-Linköpings universitet,Hälsouniversitetet,Klinisk immunologi (author)

This study aimed at investigating if selective ex vivo immune deviation of myelin-specific cytokine secretion towards Th2 is possible in blood cells from patients with multiple sclerosis (MS). Interleukin (IL)-4 (Th2) and interferon-γ (Th1) secreting cells were recorded by ELISPOT in 13 MS patients. Deviation was successful in 10 patients. Interleukin-4 alone was most effective in inducing myelin-specific immune deviation in MS patients whereas IL-1 or IL-15 in combination with IL-4 did not improve the results. Further studies and improvements are needed before ex vivo immune deviation can be considered a potential treatment in patients with MS. © 2005 Elsevier B.V. All rights reserved.

Mellergård, Johan,1974-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurologi,Neurologiska kliniken(Swepub:liu)johme15 (author)
Vrethem, Magnus,1955-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurologi,Neurologiska kliniken(Swepub:liu)magvr07 (author)
Ernerudh, Jan,1952-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15 (author)
Ekerfelt, Christina,1957-Linköpings universitet,Hälsouniversitetet,Klinisk immunologi(Swepub:liu)chrek55 (author)
Linköpings universitetHälsouniversitetet (creator_code:org_t)

By the author/editor: Hallin, Elisabet ...; Mellergård, Joha ...; Vrethem, Magnus, ...; Ernerudh, Jan, 1 ...; Ekerfelt, Christ ...

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