Prevention of venous thromboembolism with an oral factor Xa inhibitor, YM150, after total hip arthroplasty. A dose finding study (ONYX-2).

• Anticoagulant prophylaxis substantially reduces the risk of venous thromboembolism (VTE) after major orthopedic surgery. The direct factor Xa inhibitor YM150 is currently under investigation for the prevention of VTE, stroke and ischemic vascular events in patients after orthopedic surgery, with atrial fibrillation and with acute coronary syndrome, respectively.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Keyword

Administration

Oral

Adult

Aged

Aged

80 and over

Arthroplasty

Replacement

Hip

adverse effects

Dose-Response Relationship

Drug

Double-Blind Method

Enoxaparin

administration & dosage

adverse effects

Factor Xa

antagonists & inhibitors

Fibrinolytic Agents

administration & dosage

adverse effects

Humans

Incidence

Logistic Models

Middle Aged

Phlebography

Postoperative Hemorrhage

chemically induced

Risk Assessment

Surgical Procedures

Elective

Time Factors

Treatment Outcome

Venous Thromboembolism

etiology

mortality

prevention & control

radiography

Young Adult

Publication and Content Type

ref (subject category)

art (subject category)