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Short-time infusion...
Short-time infusion of oxaliplatin in combination with capecitabine (XELOX30) as second-line therapy in patients with advanced colorectal cancer after failure to irinotecan and 5-fluorouracil
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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Elsevier BV,2006
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-36136
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-36136URI
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https://doi.org/10.1093/annonc/mdj060DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-25381URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1932412URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: The efficacy of oxaliplatin combined with capecitabine (XELOX) as second-line therapy in patients with advanced colorectal cancer (ACRC) resistant to irinotecan is not well established. Oxaliplatin induces acute, cold-induced neuropathy in most patients. The incidence is claimed to be infusion rate-dependent and therefore a 2-h infusion is recommended. Patients and methods: For practical and economic reasons, but also for patient's convenience, we performed a phase II study to examine XELOX30 (capecitabine 1000 mg/m2 orally twice daily on days 1-14 and oxaliplatin 130 mg/m2 as a 30 min infusion on day 1) in patients with ACRC resistant to irinotecan. In addition the pharmacokinetics of oxaliplatin was studied. Results: From November 2002 to September 2003, 70 patients with ACRC were treated with XELOX30. Median age was 62 (range 33-74 years) years and median performance status was 1 (range 0-2). The median number of courses was four (range 1-12) and median cumulative dose of oxaliplatin was 530 (range 125-1560) mg/m2. The response rate was 17% (95% CI 10-23), median time to progression (TTP) was 5.4 months (95% CI 4.6-6.4) and median survival 9.5 months (95% CI 8.5-11.2). White blood cell count (WBC) and performance status were significantly correlated to TTP. Neurotoxicity was moderate: grade 1 56%, grade 2 17% and grade 3 6%. Other grade 3 toxicities were nausea/ vomiting 9%, diarrhoea 14% and PPE 8%. The maximum blood concentration and total body clearance of oxaliplatin was higher than previously reported in studies examining 2-h infusions, but the volume of distribution and terminal half-life was in close agreement with previous results. Conclusion: XELOX30 is a very convenient second-line regimen in ACRC with an activity and safety profile similar to other oxaliplatin schedules. © 2005 European Society for Medical Oncology.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sörbye, H
(author)
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Ehrsson, H
(author)
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Fokstuen, T
(author)
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Mortensen, JP
(author)
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Baltesgard, L
(author)
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Tveit, KM
(author)
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Ögreid, D
(author)
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Starkhammar, Hans,1948-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US(Swepub:liu)hanst87
(author)
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Wallin, I
(author)
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Qvortrup, C
(author)
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Glimelius, BKarolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
(author)
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Linköpings universitetHälsouniversitetet
(creator_code:org_t)
Related titles
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In:Annals of Oncology: Elsevier BV17:2, s. 252-2580923-75341569-8041
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Pfeiffer, P
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Sörbye, H
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Ehrsson, H
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Fokstuen, T
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Mortensen, JP
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Baltesgard, L
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Tveit, KM
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Ögreid, D
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Starkhammar, Han ...
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Wallin, I
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Qvortrup, C
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Glimelius, B
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Annals of Oncolo ...
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Linköping University
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Uppsala University
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Karolinska Institutet