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  • Yu, QunyanDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts (author)

Requirement for CDK4 kinase function in breast cancer

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Elsevier BV,2006
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-36168
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-36168URI
  • https://doi.org/10.1016/j.ccr.2005.12.012DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cyclin D1 is overexpressed in the majority of human breast cancers. We previously found that mice lacking cyclin D1 are resistant to mammary carcinomas triggered by the ErbB-2 oncogene. In this study, we investigated which function of cyclin D1 is required for ErbB-2-driven mammary oncogenesis. We report that the ability of cyclin D1 to activate cyclin-dependent kinase CDK4 underlies the critical role for cyclin D1 in breast cancer formation. We also found that the continued presence of CDK4-associated kinase activity is required to maintain breast tumorigenesis. We analyzed primary human breast cancers and found high cyclin D1 levels in a subset (∼25%) of ErbB-2-overexpressing tumors. We propose that this subset of breast cancer patients might benefit from inhibiting CDK4 kinase.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sicinska, EwaDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts (author)
  • Geng, YanDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts (author)
  • Ahnström, Marie,1976-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)marah62 (author)
  • Zagozdzon, AgnieszkaDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts (author)
  • Kong, YinxinDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts (author)
  • Gardner, HumphreyDepartment of Research Pathology, Biogen Idec, Cambridge, Massachusetts (author)
  • Kiyokawa, HiroakiDepartment of Molecular Pharmacology and Biochemical Chemistry, Northwestern University, Chicago, Illinois (author)
  • Harris, Lyndsay NDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts and Department of Medical Oncology, Dana-Farber Cancer Institute, and Brigham and Women's Hospital, Boston, Massachusetts (author)
  • Stål, Olle,1952-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)ollst87 (author)
  • Sicinski, PiotrDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts (author)
  • Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MassachusettsOnkologi (creator_code:org_t)

Related titles

  • In:Cancer Cell: Elsevier BV9:1, s. 23-321535-61081878-3686

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