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Requirement for CDK...
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Yu, QunyanDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts
(author)
Requirement for CDK4 kinase function in breast cancer
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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Elsevier BV,2006
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-36168
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-36168URI
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https://doi.org/10.1016/j.ccr.2005.12.012DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Cyclin D1 is overexpressed in the majority of human breast cancers. We previously found that mice lacking cyclin D1 are resistant to mammary carcinomas triggered by the ErbB-2 oncogene. In this study, we investigated which function of cyclin D1 is required for ErbB-2-driven mammary oncogenesis. We report that the ability of cyclin D1 to activate cyclin-dependent kinase CDK4 underlies the critical role for cyclin D1 in breast cancer formation. We also found that the continued presence of CDK4-associated kinase activity is required to maintain breast tumorigenesis. We analyzed primary human breast cancers and found high cyclin D1 levels in a subset (∼25%) of ErbB-2-overexpressing tumors. We propose that this subset of breast cancer patients might benefit from inhibiting CDK4 kinase.
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Sicinska, EwaDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts
(author)
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Geng, YanDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts
(author)
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Ahnström, Marie,1976-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)marah62
(author)
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Zagozdzon, AgnieszkaDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts
(author)
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Kong, YinxinDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts
(author)
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Gardner, HumphreyDepartment of Research Pathology, Biogen Idec, Cambridge, Massachusetts
(author)
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Kiyokawa, HiroakiDepartment of Molecular Pharmacology and Biochemical Chemistry, Northwestern University, Chicago, Illinois
(author)
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Harris, Lyndsay NDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts and Department of Medical Oncology, Dana-Farber Cancer Institute, and Brigham and Women's Hospital, Boston, Massachusetts
(author)
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Stål, Olle,1952-Linköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)ollst87
(author)
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Sicinski, PiotrDepartment of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts
(author)
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Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MassachusettsOnkologi
(creator_code:org_t)
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In:Cancer Cell: Elsevier BV9:1, s. 23-321535-61081878-3686
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Yu, Qunyan
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Sicinska, Ewa
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Kong, Yinxin
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Cancer Cell
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