Search: (LAR1:lu) pers:(Gustafsson Mats) pers:(Blomqvist Göran) conttype:(refereed) >
Wear particles gene...
Wear particles generated from studded tires and pavement induces inflammatory reactions in mouse macrophage cells
-
- Lindbom, John, 1960- (author)
- Linköpings universitet,Yrkes- och miljömedicin,Hälsouniversitetet
-
- Gustafsson, Mats (author)
- Swedish National Road and Transport Research Institute, Linköping, Sweden
-
- Blomqvist, Göran (author)
- Swedish National Road and Transport Research Institute, Linköping, Sweden
-
show more...
-
- Dahl, Andreas (author)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Division of Ergonomics and Aerosol Technology, Lund University, Lund, Sweden
-
- Gudmundsson, Anders (author)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Division of Ergonomics and Aerosol Technology, Lund University, Lund, Sweden
-
- Swietlicki, Erik (author)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Kärnfysik,Fysiska institutionen,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Nuclear physics,Department of Physics,Faculty of Engineering, LTH,Division of Nuclear Physics, Lund University, Lund, Sweden
-
- Ljungman, Anders, 1958- (author)
- Linköpings universitet,Yrkes- och miljömedicin,Hälsouniversitetet
-
show less...
-
(creator_code:org_t)
- 2007-05-22
- 2007
- English.
-
In: Chemical Research in Toxicology. - : American Chemical Society (ACS). - 0893-228X .- 1520-5010. ; 20:6, s. 937-946
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles generated from traffic have been recognized as a major contributing source to the overall particle load, especially in the Nordic countries where studded tires are used. The aim of this study was to further investigate and compare the ability to induce inflammatory mediators of different traffic-related wear particles collected from an urban street, a subway station, and studded tire-pavement wear. Inflammatory effects were measured as induction of nitric oxide (NO), IL-6, TNF-α, arachidonic acid (AA), and lipid peroxidation after exposure of the murine macrophage like cell line RAW 264.7. In addition, the redox potential of the particles was measured in a cell-free system. The results show that all particles tested induce IL-6, TNF-α, and NO, and those from the urban street were the most potent ones. In contrast, particles collected from a subway station were most potent to induce lipid peroxidation, A A release, and formation of ROS. Particles from studded tire-pavement wear, generated using a road simulator, were able to induce inflammatory cytokines, NO, lipid peroxidation, and ROS formation. Interestingly, particles generated from pavement containing granite as the main stone material were more potent than those generated from pavement containing quartzite as the main stone material.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database