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Diurnal and seasona...
Diurnal and seasonal variation of cholecystokinin peptides in humans
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- Lundberg, Kristina, 1978- (författare)
- Linköpings universitet,Hälsouniversitetet,Psykiatri
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- Josefsson, Ann, 1958- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Obstetrik och gynekologi,Kvinnokliniken i Linköping
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- Nordin, Conny, 1944- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Psykiatri,Psykiatriska kliniken
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: Neuropeptides. - : Elsevier BV. - 0143-4179 .- 1532-2785. ; 41:1, s. 59-63
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cholecystokinin (CCK) was determined in plasma obtained from 10 female (aged 23.4 ± SD 2.3 years) and nine male (aged 22.0 ± SD 1.4 years) healthy volunteers. Blood samples were drawn three times (8.00 a.m., 12 noon and 8.00 a.m.) on each of two sessions, one in the winter (November-December) and one in the summer (April-July). The participants had fasted (and were nicotine-free) since midnight preceding the sampling. A standardized breakfast was served after the first sampling. CCK was determined by radioimmunoassay. The area under the curve 0-24 h (AUC)CCK Winter was lower than AUCCCK Summer (F1:17 = 4.73, P = 0.0440) in the whole group of volunteers. On comparing the CCK concentrations within each session, there was an overall difference in winter (F2:36 = 14.81, P < 0.0001) as well in summer (F2:36 = 18.39, P < 0.0001). Post hoc comparisons yielded a difference between the 8.00 a.m. and 12 noon concentrations on the first day in winter (t = -3.96, P = 0.0009) as well as in summer (t = -4.64, P = 0.0002). The difference between the summer and winter AUCsCCK correlated with the difference between AUCs for temperatures in summer and winter (r = 0.58, P = 0.0089). The correlation was accounted for by the females (r = 0.73, P = 0.0171). The results are in accord with a diurnal and a seasonal variation of CCK in human plasma. © 2006 Elsevier Ltd. All rights reserved.
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- MEDICINE
- MEDICIN
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- art (ämneskategori)
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