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Active cytomegalovi...
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Gredmark, SaraKarolinska Institutet
(author)
Active cytomegalovirus replication in patients with coronary disease
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2009-07-12
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Informa UK Limited,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-40759
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-40759URI
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https://doi.org/10.1080/14017430701383755DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:115905577URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objectives. To study the prevalence of active cytomegalovirus (CMV) infection in patients with stable and unstable conditions of coronary artery disease (CAD). Design. Forty patients with acute coronary syndrome (ACS), 50 patients with stable angina and angiographically verified CAD (SA) and 50 clinically healthy controls were included. Monocytes were isolated from peripheral blood and CMV-RNA expression was determined by a nested RT-PCR assay. CMV IgM and IgG antibodies, interleukin-(IL)-6, IL-10 and CRP were measured in serum. Results. The prevalence of active CMV infection was significantly higher in patients with ACS (15%) and in patients with SA (10%) compared with controls (2%) (p < 0.001). The presence of an active CMV infection was associated with increased serum concentrations of IL-6. Conclusions. Active CMV infection was found to a larger extent in CAD patients than in healthy controls. The data indicate that CAD patients are more susceptible to reactivation of CMV and put new focus on the role of CMV in atherosclerosis.
Subject headings and genre
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cytomegalovirus
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monocytes
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coronary artery disease
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acute coronary syndrome
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Jonasson, Lena,1956-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kardiologi,Kardiologiska kliniken(Swepub:liu)lenjo59
(author)
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Van Gosliga, DjokeKarilinska Institutet
(author)
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Ernerudh, Jan,1952-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(author)
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Söderberg-Nauclér, CeciliaKarolinska Institutet
(author)
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Karolinska InstitutetHälsouniversitetet
(creator_code:org_t)
Related titles
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In:Scandinavian Cardiovascular Journal: Informa UK Limited41:4, s. 230-2341401-74311651-2006
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