Sökning: onr:"swepub:oai:DiVA.org:liu-40845" > Effects of inhibito...
Fältnamn | Indikatorer | Metadata |
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000 | 02833naa a2200337 4500 | |
001 | oai:DiVA.org:liu-40845 | |
003 | SwePub | |
008 | 091010s2007 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-408452 URI |
024 | 7 | a https://doi.org/10.1016/j.plefa.2007.10.0022 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gati, Istvan,d 1954-u Linköpings universitet,Neurologi,Hälsouniversitetet4 aut0 (Swepub:liu)istga26 |
245 | 1 0 | a Effects of inhibitors of the arachidonic acid cascade on primary muscle culture from a Duchenne muscular dystrophy patient |
264 | 1 | b Elsevier BV,c 2007 |
338 | a print2 rdacarrier | |
520 | a The aim of this study was to elucidate the mechanisms of action for potential targets of therapeutic intervention related to the arachidonic acid cascade in muscular dystrophy. Primary cultures from a Duchenne patient were used to study the expression of dystrophin-1, utrophin, desmin, neonatal myosin heavy chain (MHCn) and Bcl-2 during inhibition of phospholipase A2 (PLA2), cyclooxygenase (COX) and lipoxygenase (LOX). Hypo-osmotic treatment was applied in order to trigger Ca2+ influx and PLA2 activity. Inhibition of PLA2 and LOX with prednisolone and nordihydroguaiaretic acid (NDGA) caused a semi-quantitative increase of utrophin and Bcl-2-, and a dose-dependent, quantitative increase of desmin expression, an effect that was augmented by hypo-osmotic treatment. Our results indicate that LOX inhibitors, similarly to corticosteroids, can be beneficial in the treatment of muscular dystrophies. © 2007 Elsevier Ltd. All rights reserved. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Danielsson, Olof,d 1963-u Linköpings universitet,Neurologi,Hälsouniversitetet4 aut0 (Swepub:liu)oloda25 |
700 | 1 | a Betmark, T4 aut |
700 | 1 | a Ernerudh, Jan,d 1952-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)janer15 |
700 | 1 | a Öllinger, Karin,d 1962-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Patologi,Klinisk patologi och klinisk genetik4 aut0 (Swepub:liu)karol56 |
700 | 1 | a Dizdar Segrell, Nil,d 1960-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurologi,Neurologiska kliniken4 aut0 (Swepub:liu)nildi39 |
710 | 2 | a Linköpings universitetb Neurologi4 org |
773 | 0 | t Prostaglandins, Leukotrienes and Essential Fatty Acidsd : Elsevier BVg 77:3-4, s. 217-223q 77:3-4<217-223x 0952-3278x 1532-2823 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-40845 |
856 | 4 8 | u https://doi.org/10.1016/j.plefa.2007.10.002 |
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