SwePub
Sök i LIBRIS databas

  Extended search

(WFRF:(Sun Xiao Feng 1959 ))
 

Search: (WFRF:(Sun Xiao Feng 1959 )) > (2005-2009) > Polymorphism in the...

  • Lewander, Andreas,1973-Linköpings universitet,Hälsouniversitetet,Onkologi (author)

Polymorphism in the promoter region of the NFKB1 gene increases the risk of sporadic colorectal cancer in Swedish but not in Chinese populations

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2009-07-08
  • Informa UK Limited,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-41614
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-41614URI
  • https://doi.org/10.1080/00365520701396026DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:116127209URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective. An insertion/deletion polymorphism (-94ins/delATTG) in the promoter region of the NFKB1 gene correlates to an increased risk of ulcerative colitis, a known risk factor for colorectal cancer, but this polymorphism has not been studied in colorectal cancer patients. The purpose of this study was to investigate whether this polymorphism is related to colorectal cancer risk and clinicopathological variables. Material and methods. Case samples were taken from four groups of Swedish patients: 193 unselected patients, 90 patients with ≥3 affected 1st-degree relatives, 85 patients with 2 affected 1st-degree relatives, and 109 sporadic cancer patients, and one group of 193 unselected Chinese patients. Controls included 439 Swedish and 458 Chinese healthy individuals. Genotypes were determined by polymerase chain reaction (PCR)-restriction fragment length polymorphism. Results. The deletion increased the risk of colorectal cancer among Swedish unselected patients (OR=3.81, 95% CI: 2.17-6.69, p<0.0001 for heterozygote deletion, and OR=4.65, 95% CI: 2.43-8.89, p<0.0001 for homozygote deletion) and sporadic cancer patients (OR=7.73, 95% CI: 3.06-19.57, p<0.0001 for heterozygote deletion, and OR=6.58, 95% CI: 2.35-18.43, p<0.0001 for homozygote deletion) compared to homozygote insertion (wild-type), but not among the other Swedish or Chinese patients (p>0.05). Similar evidence was seen in age-adjusted analyses (p<0.0001). The polymorphism did not correlate to clinicopathological variables (p>0.05). Conclusions. Deletion of the polymorphism was associated with increased susceptibility to sporadic colorectal cancers in the Swedish population, but not in the Swedish patients with a family history of colorectal cancer or in Chinese patients. © 2007 Taylor & Francis.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kumar Reddy Butchi, Anil (author)
  • Gao, Jingfang,1966-Linköpings universitet,Hälsouniversitetet,Onkologi(Swepub:liu)jinga59 (author)
  • He, Lu-Jun (author)
  • Lindblom, AnnikaKarolinska Institutet (author)
  • Arbman, Gunnar (author)
  • Carstensen, John,1953-Linköpings universitet,Filosofiska fakulteten,Tema hälsa och samhälle(Swepub:liu)johca98 (author)
  • Zhang, Zhi-Yong (author)
  • Sun, Xiao-Feng,1959-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
  • Linköpings universitetHälsouniversitetet (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Gastroenterology: Informa UK Limited42:11, s. 1332-13380036-55211502-7708

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view