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NK cell apoptosis i...
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Li, WeiLinköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet
(författare)
NK cell apoptosis in coronary artery disease. Relation to oxidative stress
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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Elsevier BV,2008
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-43384
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43384URI
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https://doi.org/10.1016/j.atherosclerosis.2007.10.031DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective: Natural killer (NK) cells, key elements in initiation and modulation of immune responses, were recently found to be reduced in coronary artery disease (CAD). To clarify mechanisms behind this reduction, we here investigated NK cell apoptosis in CAD patients. Since oxidative stress has been linked to NK cell apoptosis, we related the findings to oxidative stress in vivo and evaluated the ex vivo susceptibility of NK cells to oxidized lipids. Methods and results: The number of apoptotic NK cells in peripheral blood was significantly increased in CAD patients compared to controls. Purified NK cells from CAD patients also showed a higher rate of spontaneous apoptosis ex vivo. Dose- and time-dependent effects of oxidized LDL and 7β-hydroxycholesterol (7βOH) on apoptosis and ROS production were determined in NK cells from blood donors. Thereafter, purified NK cells from CAD patients and healthy controls were exposed to the oxidized lipids in a paired design. NK cells from patients were more susceptible to apoptosis induced by oxidized LDL, in particular 7βOH, compared to cells from controls. Plasma measurements of LDL protein oxidation and lipid peroxidation did not show any differences between patients and controls. On the other hand, plasma carotenoids were significantly decreased in patients and inversely correlated to NK cell apoptosis rate. Conclusion: The rate of spontaneous NK cell apoptosis was increased in CAD patients. Although NK cells in CAD patients were more sensitive to oxidized lipids ex vivo, indicating a mechanism contributing to the reduced NK cell activity in CAD, the data could not verify an obvious link between NK cell apoptosis and increased oxidative stress in vivo. © 2007 Elsevier Ireland Ltd. All rights reserved.
Ämnesord och genrebeteckningar
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Aged Apoptosis/*immunology Carotenoids/blood Cells
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Cultured Coronary Artery Disease/*immunology/*metabolism/pathology Female Humans Killer Cells
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Natural/*metabolism/*pathology Lipid Peroxidation/immunology Lipoproteins
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LDL/blood Male Middle Aged Necros
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lidebjer, Caroline,1979-Linköpings universitet,Kardiologi,Hälsouniversitetet(Swepub:liu)carli60
(författare)
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Yuan, Ximing,1959-Linköpings universitet,Hälsouniversitetet,Experimentell patologi(Swepub:liu)ximyu81
(författare)
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Szymanowski, Aleksander,1973-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kardiologi,Kardiologiska kliniken(Swepub:liu)alesz45
(författare)
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Backteman, Karin,1960-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin(Swepub:liu)karba43
(författare)
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Ernerudh, Jan,1952-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(författare)
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Leanderson, Per,1958-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Yrkes- och miljömedicin,Yrkes- och miljömedicinskt centrum(Swepub:liu)perle80
(författare)
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Nilsson, Lennart,1971-Linköpings universitet,Hälsouniversitetet,Kardiologi(Swepub:liu)lenni29
(författare)
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Swahn, Eva,1949-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kardiologi,Kardiologiska kliniken(Swepub:liu)evasw45
(författare)
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Jonasson, Lena,1956-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kardiologi,Kardiologiska kliniken(Swepub:liu)lenjo59
(författare)
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Linköpings universitetAvdelningen för cellbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Atherosclerosis: Elsevier BV199:1, s. 65-720021-91501879-1484
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Li, Wei
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Lidebjer, Caroli ...
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Yuan, Ximing, 19 ...
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Backteman, Karin ...
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Atherosclerosis
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Linköpings universitet