Sökning: WFRF:(Zandi Sasan) >
B-lineage commitmen...
B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
-
- Månsson, Robert (författare)
- Lund University,Lunds universitet,Östergötlands Läns Landsting,Kirurgiska kliniken i Östergötland,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
-
- Zandi, Sasan, 1976- (författare)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
-
- Anderson, Kristina (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hematopoietic Stem Cell Laboratory Lund University, Sweden
-
visa fler...
-
- Mårtensson, Inga-Lill (författare)
- Laboratory of Lymphocyte Signaling and Development The Babraham Institute, Cambridge, United Kingdom
-
- Jacobsen, Sten Eirik W (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hematopoietic Stem Cell Laboratory Lund University
-
- Bryder, David (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Department of Immunology Lund University, Sweden
-
- Sigvardsson, Mikael, 1965- (författare)
- Lund University,Lunds universitet,Linköpings universitet,Hälsouniversitetet,Experimentell hematologi,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
-
visa färre...
-
(creator_code:org_t)
- American Society of Hematology, 2008
- 2008
- Engelska.
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 112:4, s. 1048-1055
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- Commitment of hematopoietic progenitor cells to B-lymphoid cell fate has been suggested to coincide with the development of PAX5-expressing B220 +CD19+ pro-B cells. We have used a transgenic reporter mouse, expressing human CD25 under the control of the B-lineage- restricted IgII1 (λ5) promoter to investigate the lineage potential of early progenitor cells in the bone marrow. This strategy allowed us to identify a reporter expressing LIN-B220- CD19-CD127 +FLT3+ SCA1lowKITlow population that displays a lack of myeloid and a 90% reduction in in vitro T-cell potential compared with its reporter-negative counterpart. Gene expression analysis demonstrated that these lineage-restricted cells express B- lineage-associated genes to levels comparable with that observed in pro-B cells. These data suggest that B-lineage commitment can occur before the expression of B220 and CD19. © 2008 by The American Society of Hematology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Animals Antigens
- CD19/*analysis Antigens
- CD45/*analysis B-Lymphocytes/chemistry/*cytology Bone Marrow Cells *Cell Lineage Hematopoietic Stem Cells/chemistry/*cytology Humans Interleukin-2 Receptor alpha Subunit Mice Mice
- Inbred C57BL Mice
- Transgenic
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Blood
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas