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Clinicopathological...
Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer
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- Xu, Bing (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Zhou, Zong-Guang (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Li, Yuan (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Wang, Ling (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Yang, Lie (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Zhou, Bin (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Liu, Hai-Li (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Song, Jun-Min (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Zeng, Yu-Jian (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Wang, Rong (author)
- Department of General Surgery West China Hospital, Sichuan University, Chengdu, China
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- Sun, Xiao-Feng, 1959- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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(creator_code:org_t)
- 2008-08-21
- 2008
- English.
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In: Oncology. - : S. Karger AG. - 0890-9091 .- 0030-2414 .- 1423-0232. ; 74:3-4, s. 229-236
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives: To investigate the expression of caspase-8 and -10 in rectal adenoma, adenocarcinoma and the corresponding normal mucosa tissue, and to clarify the relationship between their expression and clinicopathological parameters of rectal cancer. Methods: The expression of caspase-8 and -10 was determined by real-time RT-PCR and immunohistochemistry in 36 rectal adenomas, 93 rectal cancers and 93 corresponding normal rectal mucosa samples. Results: Compared with normal mucosa, the mRNA expression of caspase-8 was higher in adenomas (p = 0.003), while that of caspase-10 was lower in adenomas (p = 0.035) and cancers (p = 0.001). Immunohistochemical results showed caspase-8 up-regulation in adenomas (p = 0.014), and caspase-10 down-regulation in adenomas (p = 0.034) and cancers (p < 0.001) compared with normal mucosa samples. Cancers with poor differentiation had lower caspase-10 mRNA and protein levels than those with better differentiation (p = 0.041 and p = 0.046, respectively). The protein expression of caspase-8 and -10 was in accordance with the mRNA expression (p = 0.043 and p = 0.018, respectively). Conclusions: Caspase-8 expression was up-regulated in rectal adenomas. Caspase-10 expression was down-regulated in both rectal adenomas and cancers, and was further related to differentiation. Caspase-8 and -10 may be involved in the pathogenesis of rectal cancer. Copyright © 2008 S. Karger AG.
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- MEDICIN
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Oncology
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- By the author/editor
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Xu, Bing
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Zhou, Zong-Guang
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Li, Yuan
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Wang, Ling
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Yang, Lie
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Zhou, Bin
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Liu, Hai-Li
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Song, Jun-Min
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Zeng, Yu-Jian
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Wang, Rong
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Sun, Xiao-Feng, ...
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Oncology
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Linköping University