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  • Hedlund, P. O. (author)

Parenteral estrogen versus combined androgen deprivation in the treatment of metastatic prostatic cancer : Part 2. Final evaluation of the Scandinavian Prostatic Cancer Group (SPCG) Study No. 5

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2009-07-09
  • Informa UK Limited,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-44454
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-44454URI
  • https://doi.org/10.1080/00365590801943274DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-10334URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:116963093URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective. To compare parenteral estrogen therapy in the form of high-dose polyestradiol phosphate (PEP, Estradurin®) with combined androgen deprivation (CAD) in the treatment of prostate cancer patients with skeletal metastases. The aim of the study was to compare anticancer efficacy and adverse events, especially cardiovascular events. Material and methods. In total, 910 eligible patients with T0-4, NX, M1, G1-3 prostate cancer with an Eastern Cooperative Oncology Group performance status of 0-2 were randomized to treatment with either PEP 240mg i.m. twice a month for 2months and thereafter monthly, or flutamide (Eulexin®) 250mg t.i.d. per os in combination with either triptorelin (Decapeptyl®) 3.75mg i.m. per month or on an optional basis bilateral orchidectomy. Results. At this final evaluation of the trial 855 of the 910 patients were dead. There was no difference between the treatment groups in terms of biochemical or clinical progression-free survival or in overall or disease-specific survival. There was no difference in cardiovascular mortality, but a significant increase in non-fatal cardiovascular events in the PEP arm (p<0.05) predominantly caused by an increase in ischemic heart and heart decompensation events. There were 18 grave skeletal events in the CAD group but none in the PEP group (p=0.001). Conclusions. PEP has an anticancer efficacy equal to CAD and does not increase cardiovascular mortality in metastasized patients, but carries a significant risk of non-fatal cardiovascular events, which should be balanced against the skeletal complications in the CAD group. It is feasible to use Estradurin in the primary or secondary endocrine treatment of metastasized patients without prominent cardiac risk factors and especially those with osteoporosis. © 2008 Taylor & Francis.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Damber, J. E. (author)
  • Hagerman, I.Karolinska Institutet (author)
  • Haukaas, S (author)
  • Henriksson, P.Karolinska Institutet (author)
  • Iversen, P. (author)
  • Johansson, R. (author)
  • Klarskov, P (author)
  • Lundbeck, F. (author)
  • Rasmussen, F. (author)
  • Varenhorst, Eberhard,1937-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Urologi,Urologiska kliniken i Östergötland(Swepub:liu)ebeva05 (author)
  • Viitanen, J. (author)
  • Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003 (author)
  • Karolinska InstitutetHälsouniversitetet (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Urology and Nephrology: Informa UK Limited42:3, s. 220-2290036-55991651-2065

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