WFRF:(Fransson Göran)
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- Aspelin, P.Karolinska Institutet (författare)
Cost-effectiveness of iodixanol in patients at high risk of contrast-induced nephropathy
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
- Elsevier BV,2005
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-45524
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45524URI
- https://doi.org/10.1016/j.ahj.2004.07.020DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1929637URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Background: Acute renal failure after contrast-induced nephropathy is a clinically important and costly complication after the use of iodine-based contrast media. We investigated the cost and cost-effectiveness of 2 contrast media in patients at high risk of contrast-induced nephropathy. Methods: The analyses were based on a randomized, prospective, multinational clinical study comparing the nephrotoxic effects of an isosmolar nonionic contrast medium, iodixanol, with those of a low-osmolar nonionic contrast medium, iohexol. Resource utilization data were obtained from the study and from a retrospective review of patients' hospital records. Swedish, German, and French unit prices were applied to resources used. Between-group differences in average costs were analyzed using a nonparametric bootstrap method. Results: Resource utilization data for 125 patients were analyzed. Seven contrast media-related serious adverse reactions, of which 6 were acute renal failures, were noted in 6 patients receiving iohexol. Two patients in the iodixanol group had 1 nonserious reaction each. The mean hospitalization cost per patient was €489, €573, and €393 lower after iodixanol than after iohexol using Swedish, German, and French unit prices, respectively. The mean per-patient costs of treating adverse drug reactions were €371, €399, and €445 lower after iodixanol than after iohexol, using the respective unit prices (P = 0.01). Iodixanol was cost-effective compared with iohexol, with both lower costs and better effects related to fewer adverse drug reactions. Conclusions: The isosmolar contrast medium iodixanol appears to be cost-effective when compared with a low-osmolar contrast medium, iohexol, in diabetic patients with renal impairment undergoing angiography. © 2005, Elsevier Inc. All rights reserved.
Ämnesord och genrebeteckningar
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Aubry, P.Department of Cardiology, Ctr. Hosp. Universitaire Bichat, Paris, France (författare)
- Fransson, Sven GöranÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Institutionen för medicin och vård,Kardiologiska kliniken(Swepub:liu)svefr70 (författare)
- Strasser, R.Department of Cardiology, Heart Center, University of Technology, Dresden, Germany (författare)
- Willenbrock, R.Department of Cardiology, Hospital St. Elisabeth, Halle, Germany (författare)
- Lundkvist, J.Karolinska Institutet (författare)
- Karolinska InstitutetDepartment of Cardiology, Ctr. Hosp. Universitaire Bichat, Paris, France (creator_code:org_t)
Sammanhörande titlar
- Ingår i:American Heart Journal: Elsevier BV149:2, s. 298-3030002-87031097-6744
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- American Heart J ...
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