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Fanconi anaemia pro...
Fanconi anaemia proteins : Major roles in cell protection against oxidative damage
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- Pagano, G. (author)
- Italian National Cancer Institute, G. Pascale Foundation, Paediatric Oncology Research Centre, Mercogliano (AV), Italy, Istituto Nazionale Tumori, Fondazione G. Pascale, v. M. Semmola, I-80131 Naples, Italy
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- Youssoufian, H. (author)
- Clinical Discovery, Bristol-Myers Squibb Company, Princeton, NJ, United States
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- Anak, S.S. (author)
- Dept. of Paediat. Haematol./Oncolog., Istanbul Univ. School of Medicine, Istanbul, Turkey
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- Brunk, Ulf (author)
- Linköpings universitet,Hälsouniversitetet,Farmakologi
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- Calzone, R. (author)
- Department of Genetics, Elena d'Aosta Hospital, Naples, Italy
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- Clarke, A.A. (author)
- Department of Haematology, St. George's Hosp. Medical School, University of London, London, United Kingdom
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- Degan, P. (author)
- Italian National Cancer Institute, Genoa, Italy
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- D'Ischia, M. (author)
- Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain
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- Dunster, C. (author)
- Division of Life Sciences, King's College, London, United Kingdom
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- Giudice, A. (author)
- Italian National Cancer Institute, Genoa, Italy
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- Iaccarino, M. (author)
- Italian National Cancer Institute, Genoa, Italy
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Hirsch-Kauffmann, M. (author)
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- Kelly, F.J. (author)
- Division of Life Sciences, King's College, London, United Kingdom
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- Lloret, A. (author)
- Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain
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- Malorni, W. (author)
- Italian Natl. Inst. of Hlth. (ISS), Rome, Italy
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- Manini, P. (author)
- Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain
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- Masella, R. (author)
- Italian Natl. Inst. of Hlth. (ISS), Rome, Italy
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- Nobili, B. (author)
- Department of Paediatrics, 2nd Naples University, Naples, Italy
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- Pallardo, F.V. (author)
- Pallardó, F.V., Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain
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- Schweiger, M. (author)
- Department of Biochemistry, Free University Berlin, Berlin, Germany
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- Vuttariello, E. (author)
- Italian National Cancer Institute, Genoa, Italy
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- Youssoufian, G. (author)
- John Whiterspoon Middle School, Princeton, NJ, United States
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- Zatterale, A. (author)
- Department of Genetics, Elena d'Aosta Hospital, Naples, Italy
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Italian National Cancer Institute, G Pascale Foundation, Paediatric Oncology Research Centre, Mercogliano (AV), Italy, Istituto Nazionale Tumori, Fondazione G. Pascale, v. M. Semmola, I-80131 Naples, Italy Clinical Discovery, Bristol-Myers Squibb Company, Princeton, NJ, United States (creator_code:org_t)
- 2003-05-19
- 2003
- English.
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In: Bioessays. - : Wiley. - 0265-9247 .- 1521-1878. ; 25:6, s. 589-595
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Fanconi anaemia (FA) is a cancer-prone genetic disorder that is characterised by cytogenetic instability and redox abnormalities. Although rare subtypes of FA (B, D1 and D2) have been implicated in DNA repair through links with BRCA1 and BRCA2, such a role has yet to be demonstrated for gene products of the common subtypes. Instead, these products have been strongly implicated in xenobiotic metabolism and redox homeostasis through interactions of FANCC with cytochrome P-450 reductase and with glutathione S-transferase, and of FANCG with cytochrome P-450 2E1, as well as redox-dependent signalling through an interaction between FANCA and Akt kinase. We hypothesise that FA proteins act directly (via FANCC and FANCG) and indirectly (via FANCA, BRCA2 and FANCD2) with the machinery of cellular defence to modulate oxidative stress. The latter interactions may co-ordinate the link between the response to DNA damage and oxidative stress parameters (3, 6-12). © 2003 Wiley Periodicals, Inc.
Keyword
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- MEDICIN
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Bioessays
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Pagano, G.
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Youssoufian, H.
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Anak, S.S.
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Brunk, Ulf
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Calzone, R.
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Clarke, A.A.
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Degan, P.
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D'Ischia, M.
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Dunster, C.
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Giudice, A.
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Iaccarino, M.
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Hirsch-Kauffmann ...
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Kelly, F.J.
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Lloret, A.
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Malorni, W.
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Manini, P.
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Masella, R.
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Nobili, B.
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Pallardo, F.V.
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Schweiger, M.
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Vuttariello, E.
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Youssoufian, G.
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Zatterale, A.
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Bioessays
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Linköping University