Comparison of ethyl glucuronide in hair with phosphatidylethanol in whole blood as post-mortem markers of alcohol abuse

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Kronstrand Robert) > Comparison of ethyl...

Details
MARC

Bendroth, PeterDepartment of Forensic Medicine, Lund, Sweden (author)

Comparison of ethyl glucuronide in hair with phosphatidylethanol in whole blood as post-mortem markers of alcohol abuse

Article/chapterEnglish2008

Publisher, publication year, extent ...

Elsevier BV,2008
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:liu-46633
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-46633URI
https://doi.org/10.1016/j.forsciint.2007.09.012DOI
https://lup.lub.lu.se/record/1207245URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:116848304URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Ethyl glucuronide (EtG) is a direct metabolite of ethanol and has been used as a marker of alcohol abuse in both urine and hair. This study investigated the value of EtG testing in post-mortem hair for diagnostic improvement of alcohol abuse in forensic medicine. Material from 70 consecutive medico-legal autopsies was collected in accordance with the recommendations on ethics by the Swedish National Board of Forensic Medicine. A method for determination of EtG in hair samples was developed using ultra performance liquid chromatography/electrospray tandem mass spectrometry (UPLC/ESI-MS/MS; LOQ, 2.5 pg/mg). The result of the EtG analysis was compared with the findings of phosphatidylethanol (PEth) in femoral whole blood, as measured by high performance liquid chromatography with an evaporative light-scattering detector (HPLC–ELSD; LOQ, 0.22 μmol/l). Evaluation of liver histology and anamnestic evidence of alcohol abuse of the deceased were taken in consideration for the interpretation. Measurable levels of EtG were present in 49 of the 70 autopsy cases whereas PEth was present in 36. Thirty-nine cases had EtG levels above the cutoff limit (≥30 pg/mg) compared with 29 for PEth (≥0.7 μmol/l). Fifteen cases had EtG as exclusive indicator for alcohol abuse compared with four cases for PEth. These findings suggest that measurements of EtG in hair may provide improved diagnostic information on alcohol abuse, due to a long retrospective time-window for detection and stability of EtG in hair in the decaying cadaver. However, an EtG level below the cutoff does not completely exclude previous alcohol abuse.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Annan medicin och hälsovetenskap Rättsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Other Medical and Health Sciences Forensic Science hsv//eng
Alcohol marker
Ethyl glucuronide
Forensic medicine
Hair
Phosphatidylethanol
MEDICINE
MEDICIN
alcohol marker
phosphatidylethanol
ethyl glucuronide
hair
forensic
medicine

Added entries (persons, corporate bodies, meetings, titles ...)

Kronstrand, RobertLinköpings universitet,Rättsgenetik,Hälsouniversitetet(Swepub:liu)robkr41 (author)
Helander, AndersKarolinska Institutet (author)
Greby, JesperDepartment of Forensic Medicine, Lund, Sweden (author)
Stephanson, NikolaiKarolinska Institutet (author)
Krantz, PeterLund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine,Department of Forensic Medicine, Lund, Sweden(Swepub:lu)fore-pkr (author)
Department of Forensic Medicine, Lund, SwedenRättsgenetik (creator_code:org_t)

Related titles

In:Forensic Science International: Elsevier BV176:1, s. 76-810379-07381872-6283

Internet link

Find in a library

Forensic Science International (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Bendroth, Peter; Kronstrand, Robe ...; Helander, Anders; Greby, Jesper; Stephanson, Niko ...; Krantz, Peter

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Other Medical an ...; and Forensic Science

Articles in the publication: Forensic Science ...

By the university: Linköping University; Lund University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se