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- Davydova, B.Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland (författare)
Coxsackievirus immunization delays onset of diabetes in non-obese diabetic mice
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
- 2003-02-24
- Wiley,2003
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-46679
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-46679URI
- https://doi.org/10.1002/jmv.10339DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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Anmärkningar
- Enteroviruses may be involved in the pathogenesis of Type 1 diabetes through different mechanisms including triggering of autoimmunity. The effect of immunization with coxsackievirus B4-E2 on diabetes incidence was studied in the non-obese diabetic mice, an animal model for human autoimmune insulin-dependent diabetes mellitus. The immunization delayed the onset of diabetes in the mice, and the effect was mediated at least partially by virus immunization-activated splenocytes as demonstrated by adoptive transfer experiments. Immunization resulted in a strong humoral immune response against the immunizing virus, formalin-inactivated coxsackievirus B4-E2. Cell-mediated immune responseto virus antigen was characterised by interferon gamma and interleukin 10 secretion. The immunization also resulted in increased antibody levels against several beta-cell autoantigens. By using epitope mapping we were able to show that in addition to reactivity with the known epitopes of viral proteins and tyrosine phosphatase A-2 or heat shock protein 60, responses to some other regions of autoantigens were enhanced. In preproinsulin, the response was restricted against an antigenic region earlier identified as DR4-dependent epitope. This reactivity can not be explained by homologous amino acid sequences and it is possible that enterovirus immunization might change the autoantigen specific TH1/TH2 balance in non-obese diabetic mice. In conclusion, our results suggest that coxsackievirus immunization increased humoral immune response to beta cell autoantigens and this was associated with a less destructive pathology for spontaneous diabetes in non-obese diabetic mice. © 2003 Wiley-Liss, Inc.
Ämnesord och genrebeteckningar
- Antibodies
- Beta-cell autoantigen
- Coxsackievirus
- Enterovirus
- Immunization
- Insulin-dependent diabetes mellitus
- Non-obese diabetic mice
- T-cell responses
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Harkonen, T.Härkönen, T., Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland (författare)
- Kaialainen, S.Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland (författare)
- Hovi, T.Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland (författare)
- Vaarala, OutiLinköpings universitet,Hälsouniversitetet,Pediatrik(Swepub:liu)outva41 (författare)
- Roivainen, M.Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland (författare)
- Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, FinlandHärkönen, T., Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of Medical Virology: Wiley69:4, s. 510-5200146-66151096-9071
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- Davydova, B.
- Harkonen, T.
- Kaialainen, S.
- Hovi, T.
- Vaarala, Outi
- Roivainen, M.
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- Journal of Medic ...
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- Linköpings universitet
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