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High-Density Lipoprotein Cholesterol, High-Density Lipoprotein Particle Size, and Apolipoprotein A-I : Significance for Cardiovascular Risk. The IDEAL and EPIC-Norfolk Studies
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- van, der Steeg W.A. (författare)
- van der Steeg, W.A., Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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- Holme, I. (författare)
- Center for Preventive Medicine, Ullevål University Hospital, Oslo, Norway
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- Boekholdt, S.M. (författare)
- Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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- Larsen, M.L. (författare)
- Department of Medicine-Cardiology A, Århus, Denmark
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- Lindahl, C. (författare)
- Pfizer Sweden, Täby, Sweden
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- Stroes, E.S.G. (författare)
- Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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- Tikkanen, M.J. (författare)
- Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
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- Wareham, N.J. (författare)
- Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
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- Faergeman, O. (författare)
- Department of Medicine-Cardiology A, Århus, Denmark
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- Olsson, Anders G (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Pedersen, T.R. (författare)
- Center for Preventive Medicine, Ullevål University Hospital, Oslo, Norway
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- Khaw, K.-T. (författare)
- Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
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- Kastelein, J.J.P. (författare)
- Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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van der Steeg, WA., Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands Center for Preventive Medicine, Ullevål University Hospital, Oslo, Norway (creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 51:6, s. 634-642
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objectives: This study was designed to assess the relationship of high-density-lipoprotein cholesterol (HDL-C), HDL particle size, and apolipoprotein A-I (apoA-I) with the occurrence of coronary artery disease (CAD), with a focus on the effect of very high values of these parameters. Background: High plasma levels of HDL-C and apoA-I are inversely related to the risk of CAD. However, recent data suggest that this relationship does not hold true for very high HDL-C levels, particularly when a preponderance of large HDL particles is observed. Methods: We conducted a post-hoc analysis of 2 prospective studies: the IDEAL (Incremental Decrease in End Points through Aggressive Lipid Lowering, n = 8,888) trial comparing the efficacy of high-dose to usual-dose statin treatment for the secondary prevention of cardiovascular events, and the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk case-control study, including apparently healthy individuals who did (cases, n = 858) or did not (control patients, n = 1,491) develop CAD during follow-up. In IDEAL, only HDL-C and apoA-I were available, in EPIC-Norfolk, nuclear magnetic resonance spectroscopy-determined HDL particle sizes were also available. Results: In the IDEAL study, higher HDL-C proved a significant major cardiac event risk factor following adjustment for age, gender, smoking, apoA-I, and apoB. A similar association was observed for HDL particle size in EPIC-Norfolk. Increased risk estimates were particularly present in the high ends of the distributions. In contrast, apoA-I remained negatively associated across the major part of its distribution in both studies. Conclusions: When apoA-I and apoB are kept constant, HDL-C and HDL particle size may confer risk at very high values. This does not hold true for very high levels of apoA-I at fixed levels of HDL-C and apoB. These findings may have important consequences for assessment and treatment of CAD risk. © 2008 American College of Cardiology Foundation.
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van, der Steeg W ...
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Holme, I.
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Boekholdt, S.M.
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Larsen, M.L.
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Lindahl, C.
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Stroes, E.S.G.
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Tikkanen, M.J.
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Wareham, N.J.
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Faergeman, O.
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Olsson, Anders G
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Pedersen, T.R.
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Khaw, K.-T.
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Kastelein, J.J.P ...
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