Acute myeloid leukemia with inv(16)(p13q22): Involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Mitelman Felix) > (2000-2004) > Acute myeloid leuke...

Details
MARC

Billstrom, R.Billström, R., Department of Hematology, Lund University Hospital, Lund, Sweden, Department of Hematology, University Hospital, SE-221 85 Lund, Sweden (author)

Acute myeloid leukemia with inv(16)(p13q22) : Involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign

Article/chapterEnglish2002

Publisher, publication year, extent ...

2002-09-03
Wiley,2002
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:liu-46914
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-46914URI
https://doi.org/10.1002/ajh.10170DOI
https://lup.lub.lu.se/record/110340URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Acute myeloid leukemia (AML) with inv(16)(p13q22) or the variant t(16,16)(p13,q22), is strongly associated with the FAB subtype M4Eo. A high incidence of CNS involvement was reported in the 1980s, but otherwise little is known about the pattern of extamedullary leukemia (EML) manifestations in this AML type. We have compiled clinical and cytogenetic data on 27 consecutive AML cases with inv(16)/t(16,16) from southern Sweden. In general, these AMLs displayed the clinical features that have previously been described as characteristic for this disease entity: low median age, hyperleukocytosis, M4Eo morphology, and a favorable prognosis. However, CNS leukemia was only seen in relapse in one patient diagnosed in 1980, whereas the most common EML manifestation in our series was lymphadenopathy (5/27, 19%), most often cervical with or without gross tonsillar enlargement. A review of previously published, clinically informative cases corroborates that lymphadenopathy, with preference for the cervical region, is the most common EML at diagnosis in inv(16)-positive AML (58/175, 33%). CNS leukemia, on the other hand, has been reported in only 17% of the cases, mostly in the relapse setting, with a diminishing frequency over time, possibly due to protective effects of high-dose cytarabine. Other reported EML sites include the scalp, ovaries, and the intestine. Cervicotonsillar EML was in our series associated with a shorter duration of first remission, (P< 0.05), and may hence prove to be an important clinical parameter when deciding treatment strategies in AML with inv(16)/t(16,16). © 2002 Wiley-Liss, Inc.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
Acute myeloid leukemia
Extramedullary involvement
Inv(16)
Lymphadenopathy
Prognosis
NATURAL SCIENCES
NATURVETENSKAP

Added entries (persons, corporate bodies, meetings, titles ...)

Ahlgren, T.Department of Hematology, Malmö University Hospital, Malmö, Sweden (author)
Békássy, AlbertLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Békássy, A.N., Department of Pediatrics, Lund University Hospital, Lund, Sweden(Swepub:lu)al4445be (author)
Malm, C.Östergötlands Läns Landsting,Hematologiska kliniken (author)
Olofsson, TorLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Department of Hematology, Lund University Hospital, Lund, Sweden(Swepub:lu)efor-tol (author)
Höglund, MattiasLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Höglund, M., Department of Clinical Genetics, Lund University Hospital, Lund, Sweden(Swepub:lu)kgen-mho (author)
Mitelman, FelixLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Genetics, Lund University Hospital, Lund, Sweden(Swepub:lu)kgen-fmi (author)
Johansson, BertilLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Genetics, Lund University Hospital, Lund, Sweden(Swepub:lu)kgen-bjo (author)
Billström, R., Department of Hematology, Lund University Hospital, Lund, Sweden, Department of Hematology, University Hospital, SE-221 85 Lund, SwedenDepartment of Hematology, Malmö University Hospital, Malmö, Sweden (creator_code:org_t)

Related titles

In:American Journal of Hematology: Wiley71:1, s. 15-190361-86091096-8652

Internet link

Find in a library

American Journal of Hematology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Billstrom, R.; Ahlgren, T.; Békássy, Albert; Malm, C.; Olofsson, Tor; Höglund, Mattias; show more...; Mitelman, Felix; Johansson, Berti ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

Articles in the publication: American Journal ...

By the university: Linköping University; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se