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Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia : A retrospective study from the European Group for Blood and Marrow Transplantation

Mohty, M. (author)
Service d'Hématologie Clinique, CHU Hôtel Dieu, Université de Nantes, Nantes, France, Service d'Hématologie Clinique, CHU Hôtel-Dieu, Université de Nantes, Place Alexis Ricordeau, F-44093 Nantes, France
Labopin, M. (author)
European Group for Blood and Marrow Transplantation (EBMT), Hopital Saint-Antoine, Université de Paris 6, Pierre et Marie Curie, Paris, France
Tabrizzi, R. (author)
Centre Hospitalo-Universitaire de Bordeaux, Hôpital Haut-Leveque, Pessac, France
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Theorin, Niklas (author)
Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
Fauser, A.A. (author)
Klinik fuer Knochenmarktransplantation und Haematologie/Onkologie, Idar-Oberstein, Germany
Rambaldi, A. (author)
Ospedale Bergamo, Divisione di Ematologia, Bergamo, Italy
Maertens, J. (author)
University Hospital Gasthuisberg, Dept. of Hematology, Leuven, Belgium
Slavin, S. (author)
Hadassah University Hospital, Department of Bone Marrow Transplantation, Jerusalem, Israel
Majolino, I. (author)
Ospedale S. Camillo-Forlanini, Dept. of Hematology and BMT, Rome, Italy
Nagler, A. (author)
Tel-Aviv University, Chaim Sheba Medical Center, Tel-Hashomer, Israel
Blaise, D. (author)
Unité de Transplantation et de Thérapie Cellulaire, Institut Paoli-Calmettes, Marseille, France
Rocha, V. (author)
European Group for Blood and Marrow Transplantation (EBMT), Hopital Saint-Antoine, Université de Paris 6, Pierre et Marie Curie, Paris, France, Department of Hematology, Hopital Saint-Louis, Assistance Publique Hopitaux de Paris, Paris, France
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 (creator_code:org_t)
Ferrata Storti Foundation (Haematologica), 2008
2008
English.
In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 93:2, s. 303-306
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%, 42±10%, and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced, p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation. ©2008 Ferrata Storti Foundation.

Keyword

Acute lymphoblastic leukemia
Allogeneic SCT
MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

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