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Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia : A retrospective study from the European Group for Blood and Marrow Transplantation
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- Mohty, M. (author)
- Service d'Hématologie Clinique, CHU Hôtel Dieu, Université de Nantes, Nantes, France, Service d'Hématologie Clinique, CHU Hôtel-Dieu, Université de Nantes, Place Alexis Ricordeau, F-44093 Nantes, France
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- Labopin, M. (author)
- European Group for Blood and Marrow Transplantation (EBMT), Hopital Saint-Antoine, Université de Paris 6, Pierre et Marie Curie, Paris, France
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- Tabrizzi, R. (author)
- Centre Hospitalo-Universitaire de Bordeaux, Hôpital Haut-Leveque, Pessac, France
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- Theorin, Niklas (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
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- Fauser, A.A. (author)
- Klinik fuer Knochenmarktransplantation und Haematologie/Onkologie, Idar-Oberstein, Germany
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- Rambaldi, A. (author)
- Ospedale Bergamo, Divisione di Ematologia, Bergamo, Italy
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- Maertens, J. (author)
- University Hospital Gasthuisberg, Dept. of Hematology, Leuven, Belgium
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- Slavin, S. (author)
- Hadassah University Hospital, Department of Bone Marrow Transplantation, Jerusalem, Israel
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- Majolino, I. (author)
- Ospedale S. Camillo-Forlanini, Dept. of Hematology and BMT, Rome, Italy
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- Nagler, A. (author)
- Tel-Aviv University, Chaim Sheba Medical Center, Tel-Hashomer, Israel
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- Blaise, D. (author)
- Unité de Transplantation et de Thérapie Cellulaire, Institut Paoli-Calmettes, Marseille, France
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- Rocha, V. (author)
- European Group for Blood and Marrow Transplantation (EBMT), Hopital Saint-Antoine, Université de Paris 6, Pierre et Marie Curie, Paris, France, Department of Hematology, Hopital Saint-Louis, Assistance Publique Hopitaux de Paris, Paris, France
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(creator_code:org_t)
- Ferrata Storti Foundation (Haematologica), 2008
- 2008
- English.
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In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 93:2, s. 303-306
- Related links:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
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- This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%, 42±10%, and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced, p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation. ©2008 Ferrata Storti Foundation.
Keyword
- Acute lymphoblastic leukemia
- Allogeneic SCT
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mohty, M.
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Labopin, M.
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Tabrizzi, R.
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Theorin, Niklas
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Fauser, A.A.
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Rambaldi, A.
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Maertens, J.
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Slavin, S.
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Majolino, I.
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Nagler, A.
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Blaise, D.
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Rocha, V.
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- Articles in the publication
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Haematologica
- By the university
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Linköping University